Results 81 to 90 of about 4,114,692 (310)

Influence of temperature effects on the pylon-beam support system of cable-stayed bridges

open access: yesShenzhen Daxue xuebao. Ligong ban
In order to explore the stress characteristics of a single-tower multi-span cable-stayed bridge under system temperature effects, taking a multi-span cable-stayed bridge project as an example, a full-bridge finite element model is established based on ...
ZHAO Licai
doaj   +1 more source

Responsibility, Structural Injustice, and Structural Transformation [PDF]

open access: yesEthics & Global Politics, 2018
This author’s reply responds to five main issues raised by the commentators. The first two issues regard the concept of structural injustice and agents’ responsibility for it. What kind of responsibility is generated by structural injustice? How is it distinct from responsibility related to the liability of agents for interactional injustice ...
openaire   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Ship Load Response Test and Structural Bearing Capacity Assessment of High-Piled Wharfs

open access: yesRenmin Zhujiang, 2020
Ship loads are most frequently exerted on wharf structures,which will inevitably cause different degrees of impact on the wharfs during berthing process of ships.In order to study the influence of the loads,this paper carries out field tests on the high ...
WANG Chengqiang   +3 more
doaj  

Attitude Control and Structural Response Interaction [PDF]

open access: yes
Interaction between structural or elastic response of spacecraft and attitude control system ...
Abel, J.
core   +1 more source

Structural Basis of Response Regulator Function

open access: yesAnnual Review of Microbiology, 2019
Response regulators function as the output components of two-component systems, which couple the sensing of environmental stimuli to adaptive responses. Response regulators typically contain conserved receiver (REC) domains that function as phosphorylation-regulated switches to control the activities of effector domains that elicit output responses ...
Gao, Rong, Bouillet, Sophie, Stock, Ann
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Systematic and Quantitative Assessment of Reduced Model Resolution on the Transient Structural Response Under Wind Load

open access: yesApplied Sciences
The wind-induced response of structures is typically studied in wind tunnels either on scaled models or using numerical approaches under similar transient load conditions.
Anoop Kodakkal   +4 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Dynamic Response Simulation for a Novel Single-Point Mooring Gravity-Type Deep-Water Net Cage Under Irregular Wave and Current

open access: yesApplied Sciences
This study investigated the structural response characteristics of a novel single-point mooring gravity-type deep-water (SPM-GDW) net cage under irregular waves and currents.
Guoliang Pang   +9 more
doaj   +1 more source

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