Results 201 to 210 of about 20,510 (268)

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Benchmarking econometric, decomposable additive, and neural network methods for food inflation prediction featuring policy insights. [PDF]

Sci Rep
Javed A.
europepmc   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

New WHO guidance on mental health and well-being across government sectors. [PDF]

World Psychiatry
Funk M, Drew N, Cole C, Moro MF.
europepmc   +1 more source

Microscale Mapping of Fiber Strain and Damage in Composite Wrinkled Laminates Using Computed Tomography Assisted Wide‐Angle X‐Ray Scattering

Advanced Science, EarlyView.
This study combines full‐field tomography with diffraction mapping to quantify radial (ε002$\varepsilon _{002}$) and axial (ε100$\varepsilon _{100}$) lattice strain in wrinkled carbon‐fiber specimens for the first time. Radial microstrain gradients (−14.5 µεMPa$\varepsilon \mathrm{MPa}$−1) are found to signal damage‐prone zones ahead of failure, which ...
Hoang Minh Luong, James Trevarthen, Igor Dolbnya, Wadwan Singhapong, Nicholas Pilato, Richard Butler, Jiraphant Srisuriyachot, Alexander J. G. Lunt   +7 more
wiley   +1 more source

The Role of Quinine to Prevent Ventricular Fibrillation and ICD Shocks in Early Repolarization Syndrome. [PDF]

JACC Case Rep
Ahmed AM, Ali A, Pirah R, Adil F, Waseem M, Mohsin M.   +5 more
europepmc   +1 more source

Floating population diversity as a leading indicator of business turnover imbalance in commercial districts: A spatial panel analysis in Seoul. [PDF]

PLoS One
Jang S, An Y.
europepmc   +1 more source

A data efficient framework for analyzing structural transformation in low and middle income economies. [PDF]

Sci Rep
Katende R.
europepmc   +1 more source

Accounting for inequality in dementia prevention programmes. [PDF]

Bull World Health Organ
Daly T, Slachevsky A, Trépel D, Walsh S, Ibáñez A.   +4 more
europepmc   +1 more source