Results 181 to 190 of about 770,807 (317)

Beyond Tanimoto: a learned bioactivity similarity index enhances ligand discovery. [PDF]

Front Bioinform
Schottlender G, Prieto JM, Marti MA, Fernández Do Porto D.   +3 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A case study of the application of AI to early stage drug discovery. [PDF]

Sci Rep
Abdel-Rehim A, Soldatova LN, King RD.
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Multimodal magnetic resonance imaging synthesis via cross-modal feature fusion and hierarchical feature extraction. [PDF]

Quant Imaging Med Surg
Guo H, Zhang H, Li M.
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

TVNet: Multimodal medical image fusion by dual-branch network with vision transformer and one-shot aggregation. [PDF]

Sci Prog
Wang J, Jia W, Liu Y, Wu P, Geng P, Meng X.   +5 more
europepmc   +1 more source

FSIM: A Feature Similarity Index for Image Quality Assessment

IEEE Transactions on Image Processing, 2011
Lin Zhang, Lei Zhang, X. Mou, David Zhang   +3 more
semanticscholar   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

R2GDN: RepGhost based residual dense network for image super-resolution. [PDF]

PLoS One
Li T, Jin X, Liu Q, Liu X, Yuan Z, Liang T, Lou J, Rao Y.   +7 more
europepmc   +1 more source