Results 151 to 160 of about 5,802,132 (307)

Retrograde Balloon-Induced Anterior Mitral Leaflet Laceration: The ROBIN Technique

Journal of the Society for Cardiovascular Angiography & Interventions
Leo Kar Lok Lai, MBChB, Hussayn Alrayes, DO, Georgi Fram, MD, James C. Lee, MD, Bryan Zweig, MD, Gennaro Giustino, MD, Ahmad Jabri, MD, Brian P. O’Neill, MD, Tiberio M. Frisoli, MD, Pedro Engel Gonzalez, MD, William W. O’Neill, MD, Pedro A. Villablanca, MD   +11 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Estruturas mistas em madeira-concreto: uma técnica racional para pontes de estradas vicinais Timber-concrete composite structures: a rational technique for bridges of vicinal roads

Ciência Rural, 2009
De modo geral, a aplicação racional de materiais de construção requer o desenvolvimento ou aprimoramento de técnicas construtivas. Nesse sentido, a utilização do concreto e da madeira, materiais tradicionais e de grande aceitação em construções rurais ...
Julio Soriano, Nilson Tadeu Mascia
doaj  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Co-design of a natural fiber-timber hybrid structural system using dual-robot coreless filament winding. [PDF]

Sci Rep
Duque Estrada R, Kannenberg F, Chen TY, Guo Y, Knippers J, Menges A.   +5 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

On the stress- and strain-based fatigue behavior of welded thick-walled nodular cast iron

Fracture and Structural Integrity
Nodular cast iron (GJS) represents one of the most widely used materials for vehicle, energy and heavy machinery industry. Nevertheless, foundries struggling with the influence of local material defects in GJS like pores, shrinkages and dross often ...
Christoph Bleicher, Steffen Schoenborn, Heinz Kaufmann, Masoud Alizadeh-Sh   +3 more
doaj  

Numerical Analysis of the Load-Bearing Capacity of a Thin-Walled Perforated Beam Cooperating with Chipboard Panels in a Structural System. [PDF]

Materials (Basel)
Denisiewicz A, Socha T, Kula K, Błażejewski W, Wyjadłowski M.   +4 more
europepmc   +1 more source