Results 31 to 40 of about 4,271,392 (311)

CEACAM6 gene variants in inflammatory bowel disease. [PDF]

, 2011
The carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) acts as a receptor for adherent-invasive E. coli (AIEC) and its ileal expression is increased in patients with Crohn's disease (CD). Given its contribution to the pathogenesis of CD,
Seiderer, J., Darina Czamara, Seiderer Julia, Ochsenkühn, Thomas, Ulrich Lass, Fries, C., Beigel, F., Glas, J., Müller-Myhsok, B., Czamara, D., Bertram Müller-Myhsok, Diegelmann Julia, Fries Christoph, Tillack, Cornelia, Lass, U., Pfennig Simone, Brand, Stephan, Göke, B., Brand Stephan, Thomas Ochsenkühn, Weidinger Maria, Olszak Torsten, Beigel, Florian, Weidinger, Maria, Ochsenkühn, T., Christiane Wolf, Wolf, Christiane, Cornelia Tillack, Julia Diegelmann, Beigel Florian, Müller-Myhsok Bertram, Göke, Burkhard, Lass Ulrich, Fries, Christoph, Pfennig, S., Pfennig, Simone, Peter Lohse, Seiderer, Julia, Glas, Jürgen, Diegelmann, J., Lohse, P., Christoph Fries, Ochsenkühn Thomas, Müller-Myhsok, Bertram, Weidinger, M., Burkhard Göke, Göke Burkhard, Stephan Brand, Wolf, C., Maria Weidinger, Brand, S., Czamara, Darina, Jürgen Glas, Tillack Cornelia, Wolf Christiane, Lass, Ulrich, Czamara Darina, Lohse, Peter, Diegelmann, Julia, Simone Pfennig, Glas Jürgen, Torsten Olszak, Olszak, T., Florian Beigel, Lohse Peter, Julia Seiderer, Olszak, Torsten, Tillack, C.   +67 more
core   +2 more sources

Precision Medicine in a Community Cancer Center: Pan-Cancer DNA/RNA Sequencing of Tumors Reveals Clinically Relevant Gene Fusions

Biologics, 2023
Background: Gene fusions occur when two independent genes form a hybrid gene through genomic rearrangements, which often leads to abnormal expression and function of an encoded protein.
Sourat Darabi, Carlos E. Zuazo, David R. Braxton, Burton L. Eisenberg, Michael J. Demeure   +4 more
doaj   +1 more source

Structural variants in the bovine genome

, 2022
Genome and environment together greatly influence how an organism develops and functions. Cattle is a livestock species with high economic significance; thus, deciphering how its genome and genomic information relates to its phenotype is crucial ...
Lee, Young-Lim
core   +1 more source

Genetic Predictors of Mortality in Patients with Multiple Myeloma

The Application of Clinical Genetics, 2021
Hamza Hassan,1 Raphael Szalat1,2 1Department of Hematology and Medical Oncology, Boston University Medical Center, Boston, MA, USA; 2Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USACorrespondence: Raphael ...
Hassan H, Szalat R
doaj  

How Important Are Structural Variants for Speciation?

, 2021
Understanding the genetic basis of reproductive isolation is a central issue in the study of speciation. Structural variants (SVs); that is, structural changes in DNA, including inversions, translocations, insertions, deletions, and duplications, are ...
Zachariah Gompert, Linyi Zhang, Radka Reifová, Zuzana Halenková   +3 more
core   +1 more source

TRPV1 splice variants: structure and function [PDF]

Frontiers in Bioscience, 2010
The capsaicin receptor (TRPV1) is a non-selective cation channel predominantly expressed in specialized sensory neurons that detect painful stimuli. Although its many functional roles continue to be revealed, it has been confirmed to play a critical role in the perception of peripheral inflammatory hyperalgesia and pain.
Mark A, Schumacher, Helge, Eilers
openaire   +2 more sources

Comparison of statistical tests for association between rare variants and binary traits. [PDF]

, 2012
Genome-wide association studies have found thousands of common genetic variants associated with a wide variety of diseases and other complex traits. However, a large portion of the predicted genetic contribution to many traits remains unknown.
Nelson Matthew R., Nelson, Matthew R., John C Whittaker, John C. Whittaker (51412), Whittaker, John C., Silviu-Alin Bacanu (143389), Nelson, Matthew R, Whittaker, John C, Bacanu Silviu-Alin, Whittaker John C., Silviu-Alin Bacanu, Matthew R Nelson, Bacanu, Silviu-Alin, Matthew R. Nelson (143393)   +13 more
core   +2 more sources

Recent advances and current challenges in population genomics of structural variation in animals and plants

Frontiers in Genetics, 2022
The field of population genomics has seen a surge of studies on genomic structural variation over the past two decades. These studies witnessed that structural variation is taxonomically ubiquitous and represent a dominant form of genetic variation ...
Ivan Pokrovac, Željka Pezer
doaj   +1 more source

Comprehensive analysis of structural variants in chickens using PacBio sequencing

Frontiers in Genetics, 2022
Structural variants (SVs) are one of the main sources of genetic variants and have a greater impact on phenotype evolution, disease susceptibility, and environmental adaptations than single nucleotide polymorphisms (SNPs). However, SVs remain challenging
Jinxin Zhang, Changsheng Nie, Xinghua Li, Xiurong Zhao, Yaxiong Jia, Jianlin Han, Yu Chen, Liang Wang, Xueze Lv, Weifang Yang, Kaiyang Li, Jianwei Zhang, Zhonghua Ning, Haigang Bao, Chunjiang Zhao, Junying Li, Lujiang Qu   +16 more
doaj   +1 more source

Structural Characterization of Histone H2A Variants [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2004
protein to form chromatin, the fundamental unit of which is the nucleosome core particle (NCP). An NCP consists of two copies each of the four core histones H2A, H2B, H3, and H4. This histone octamer binds 147 base pairs of DNA around its outer surface in 1.65 tight superhelical turns (Fig. 1A) (Luger et al. 1997; Richmond and Davey 2003).
Chakravarthy, S, Bao, Y, Roberts, V A, Tremethick, David, Luger, Karolin   +4 more
openaire   +3 more sources