Results 121 to 130 of about 54,835 (250)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Remembering St. Louis individual-structural violence and acute bacterial infections in a historical anatomical collection. [PDF]

Commun Biol, 2022
Austin RM, Zuckerman M, Honap TP, Lee H, Ward GK, Warinner C, Sankaranarayanan K, Hofman CA.   +7 more
europepmc   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

Scarcity by design: famine, structural violence, and the biosocial inheritance of political deprivation. [PDF]

Front Public Health
Eftekhari A, Aker A, Uppalapati K, Wispelwey B.   +3 more
europepmc   +1 more source

Structural violence and the need for compassionate use of methadone in Mexico. [PDF]

BMC Public Health, 2022
Romero-Mendoza M, Peláez-Ballestas I, Almanza-Avendaño AM, Figueroa E.   +3 more
europepmc   +1 more source

Magnesium‐Based Transient Bioelectronics, Bio‐Optics and Bio‐Scaffolds

Advanced Functional Materials, EarlyView.
This paper reviews the state of the art and recent advances in magnesium‐based thin‐film, foils, and scaffolds for applications in transient bio‐optics, bioelectronics and tissue engineering. The design principles, fabrication methods, material properties, and integration strategies are discussed in detail.
Massimo Mariello, Yves Leterrier
wiley   +1 more source

Scabies as a manifestation of structural violence in refugee communities: a case from Rwanda. [PDF]

Int J Equity Health
Bayisenge U, Mugume P, Davey G, Zaman S.
europepmc   +1 more source

Biodegradable and Biocompatible Functional Polymers for Biomedical Applications

Advanced Functional Materials, EarlyView.
Biodegradable and biocompatible functional polymers integrate electrical, mechanical, and stimuli‐responsive functionalities while enabling programmed degradation under physiological conditions. This review introduces recent advances in conductive, shape‐memory, self‐healing, photocurable, and adhesive polymer systems, emphasizing material design ...
Won Bae Han, Shuvra Mondal, Sungkeun Han, Chan‐Hwi Eom, Venkata Ramesh Naganaboina, Suk‐Won Hwang   +5 more
wiley   +1 more source

Dismantling structural violence to enable structural transformation and consequently social inclusion. [PDF]

World Psychiatry
Jones N.
europepmc   +1 more source

Structural violence and the uncertainty of viral undetectability for African, Caribbean and Black people living with HIV in Canada: an institutional ethnography. [PDF]

Int J Equity Health, 2023
Odhiambo AJ, O'Campo P, Nelson RE, Forman L, Grace D.   +4 more
europepmc   +1 more source