Results 51 to 60 of about 4,859,963 (286)

Prison violence and the mission statement [PDF]

, 1994
A report prepared by the Prison Violence Project, Kingston, Ontario, April 16, 1994. Rudolf Martens, Chairperson; J. Campbell, Research Director. Discusses the achievements and failures of the prison system after the adoption of a "mission statement" in ...
Prison Violence Project
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Expanding the framework of childhood adversity: Structural violence and aggression in childhood

Child Protection and Practice
Background: Structural violence harms youth by preventing them from meeting basic needs for safety, belonging, dignity, and agency, leading to negative outcomes like increased aggression. Such behaviors harm children's social and emotional well-being and
Petrovic L., Baker C.N., Francois S., Wallace M., Overstreet S.   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

“If I get an ID card then maybe I might be able to find a job and move forward…” Barriers to exiting homelessness in Croatia

İstanbul Üniversitesi Sosyoloji Dergisi
One of the main aims of this study was to generate in-depth understanding of the barriers that younger people face in their attempts to exit homelessness. The housing pathways approach is used to examine how experiences of homelessness are intersected by
Lynette Šikić-mićanović, Paula Greiner   +1 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Do we really offer refuge? Using Galtung's concept of structural violence to interrogate refugee resettlement support in Aotearoa New Zealand [PDF]

, 2020
Decades after the first refugee convention was signed, the global community is still failing to meet its commitment to protect refugees from harm. In this article, we draw on Galtung’s concept of structural violence to highlight how harm can be caused ...
Rafferty, R., Anderson, Vivienne, Burgin, Anna, Rachel Rafferty, Anna Burgin, Vivienne Anderson   +5 more
core   +1 more source