Results 81 to 90 of about 4,859,963 (286)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Specialist family violence services: the heart of an effective family violence system
, 2015 The Victorian Royal Commission into Family Violence is an extraordinary opportunity to interrogate and strengthen the family system in this state. Unprecedented increase in family violence incidents has placed demands on the system - the specialist ...
Domestic Violence Victoria
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EDUCATION FOR PEACE IN HIGH SCHOOL, IS THAT POSSIBLE?
Ra Ximhai, 2015 In this trial it is discuss with particular attention the troubles surrounding the teachers and the Education for peace. Currently the teachers in high school education find themselves in an unprecedented situation due to the recent obligatory nature of ...
Alma Delia Hernández Román
doaj
VICTIM-BLAMING AND THE CRISIS OF REPRESENTATION IN THE VIOLENCE PREVENTION FIELD
International Journal of Child, Youth & Family Studies, 2019 In this article, the authors apply response-based practice to highlight the ways in which victims are blamed in cases of violence. They problematize and explore the misrepresentation of violence across academic disciplines and institutional systems ...
Elizabeth Fast +1 more
doaj +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Séance 5 - Violence et sommeil : une exploration
, 2020 Jeudi 13 Février | 17 h Salle Claude Simon, Maison de la Recherche de la Sorbonne Nouvelle - 4, rue des Irlandais, Paris (Ve) Violence et sommeil : non seulement rien ne semble relier ces deux expériences, mais on pourrait même dire qu’elles sont,
La question de la violence
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Exploring carceral food systems
Canadian Food StudiesThere is growing recognition of the inextricable relationship between food and punishment, a relationship buttressed by hyper-capitalism, colonialism, racism, and other harmful approaches to social control.
Ami Stearns, Amanda Wilson
doaj +1 more source
THE SPECTRUM OF VISIBILITY: YOUTH EXPERIENCES OF MARGINALIZATION AND HOMELESSNESS
International Journal of Child, Youth & Family Studies, 2016 In this paper, we present some of the results of a youth participatory action research (Y-PAR) project that involved youth aged 16 to 20 who reported being marginalized in their community, primarily due to a lack of stable or consistent housing ...
Jane Robson +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
, 2017 Copy of powerpoint slides that describe domestic violence and how to ...
Domestic Violence Services of Snohomish County
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