Results 131 to 140 of about 20,557 (293)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Lychnos, 2009 From the 1970’s onward, comparative literature has held a unique position among the humanities with regard to the reception, development and application of theory.
Michael Gustavsson
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A new perspective of Aristotle's theory of vision: analysis of the "psycho-physical" intertwined mechanism of vision. [PDF]
Front Psychol, 2023 Zhao Q.
europepmc +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Covid, critical realism and category-mistake. [PDF]
Int J Health Plann Manage, 2022 Paton C.
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Entre el estructuralismo y su post: modelos de significación en Roland Barthes
Bajo Palabra, 2016 La obra de Roland Barthes se ha prestado a muy heterogéneas clasificaciones entre las que destacan aquellas que la adscriben al estructuralismo y al postestructuralismo.
R. García Murillo
doaj
From signals to music: a bottom-up approach to the structure of neuronal activity. [PDF]
Front Syst Neurosci, 2023 Noel GD, Mugno LE, Andres DS.
europepmc +1 more source