Results 201 to 210 of about 2,315 (264)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Non-Invasive Device-Mediated Drug Delivery to the Brain across the Blood-Brain Barrier. [PDF]

Pharmaceutics
Tashima T, Tournier N.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

An easier way to die?-A qualitative interview study on specialist palliative care team members' views on dying under sedation. [PDF]

Palliat Med
Bazata J, Meesters S, Bozzaro C, Handtke V, Schildmann J, Heckel M, Ostgathe C, Bausewein C, Schildmann E, SedPall Study Group.   +9 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Qualitative (pure) mathematics as an alternative to measurement. [PDF]

Front Psychol
Linkov V.
europepmc   +1 more source

We choose to go. [PDF]

Sleep Adv
Lydic R.
europepmc   +1 more source

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Structure Comparison and Structure Patterns

Journal of Computational Biology, 2000
This article investigates aspects of pairwise and multiple structure comparison, and the problem of automatically discover common patterns in a set of structures. Descriptions and representation of structures and patterns are described, as well as scoring and algorithms for comparison and discovery.
Ingvar Eidhammer, Inge Jonassen, William R. Taylor   +2 more
openaire   +2 more sources

Structures, Structures, and Structures

Angewandte Chemie International Edition in English, 1992
For quantum chemical statements about the stabilities of molecules which serve as incentives for the synthesis of new compounds, a structure determined by calculations according to the state of the art must be identified as corresponding to a minimum on the energy hypersurface. That kinetics must also not be disregarded, is the contribution of Pople et
openaire   +1 more source