Results 161 to 170 of about 5,429,668 (289)

The megaproject paradox in urban street food areas: structural inertia and forced resilience in the Global South. [PDF]

Front Sociol
Rahman SA, Syafrini D, Fariza MR, Permata BD, Ramadhani EO, Fadila A, Alyasin R, Putri FNN, Fauziah G, Permana RA.   +9 more
europepmc   +1 more source

A Structural Theory of Imperialism

Journal of Peace Research, 1971
openaire   +3 more sources

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Governing waste and producing environmental subjects: a sociological analysis of decentralised solid waste management model in Kerala, India. [PDF]

Front Sociol
Arya AS, Shukla R.
europepmc   +1 more source

Structural Witness Theory – Structural Witness Theory

Structural Witness Theory is a novel framework that investigates the minimal structural entities required to certify a given mathematical property. For a property P(X) defined on a set X, we seek a minimal witness W such that W is a subset of X and the existence of W alone guarantees P(X).
openaire   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Structural Recurrence Theory — Structural Reappearance Theory

Structural recurrence theory investigates the phenomenon whereby a particular structural pattern re‑emerges at higher levels of a hierarchical system. Unlike conventional recursion, which focuses on the repeated application of a function to an object, structural recurrence concerns the persistence of a pattern itself across different scales. This paper
openaire   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Structural Minimality Theory – Structural Minimality Theory

The present work introduces Structural Minimality Theory, a framework for determining the smallest structural configuration that suffices to guarantee the validity of a given mathematical statement. By formalizing the notion of a Minimal Supporting Structure (MSS), the theory provides a systematic method to identify the minimal collections, operations,
openaire   +1 more source