Results 1 to 10 of about 22,404,851 (343)
Highly accurate protein structure prediction with AlphaFold
Nature, 2021 Proteins are essential to life, and understanding their structure can facilitate a mechanistic understanding of their function. Through an enormous experimental effort1–4, the structures of around 100,000 unique proteins have been determined5, but this ...
J. Jumper +33 more
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Evolutionary-scale prediction of atomic level protein structure with a language model
bioRxiv, 2022 Artificial intelligence has the potential to open insight into the structure of proteins at the scale of evolution. It has only recently been possible to extend protein structure prediction to two hundred million cataloged proteins.
Zeming Lin +14 more
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The Large Scale Structure of Space-Time
, 2023 First published in 1973, this influential work discusses Einstein's General Theory of Relativity to show how two of its predictions arise: first, that the ultimate fate of many massive stars is to undergo gravitational collapse to form 'black holes'; and
S. Hawking, G. Ellis
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Advances in Materials Science and Engineering, 2021 This work has launched a comprehensive investigation on the macro performance and micro structure of mass concrete produced with alkali-active sand slate powder (ASSP) for use as the mineral admixture and a thorough analysis on its technical and economic
Xia Chen +3 more
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A novel small molecule, AS1, reverses the negative hedonic valence of noxious stimuli
BMC Biology, 2023 Background Pain is the primary reason people seek medical care, with chronic pain affecting ~ 20% of people in the USA. However, many existing analgesics are ineffective in treating chronic pain, while others (e.g., opioids) have undesirable side effects.
Kali Esancy +6 more
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UCSF ChimeraX: Tools for structure building and analysis
Protein Science, 2023 Advances in computational tools for atomic model building are leading to accurate models of large molecular assemblies seen in electron microscopy, often at challenging resolutions of 3–4 Å. We describe new methods in the UCSF ChimeraX molecular modeling
Elaine C. Meng +6 more
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
Science, 2020 Structure of the nCoV trimeric spike The World Health Organization has declared the outbreak of a novel coronavirus (2019-nCoV) to be a public health emergency of international concern.
D. Wrapp +7 more
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Achieving gas pressure-dependent luminescence from an AIEgen-based metal-organic framework
Nature Communications, 2022 Compounds displaying aggregation-induced emission behavior may have application in the preparation of smart materials. Here, the authors report a luminogen-containing metal-organic framework for which luminescence intensity changes are observed in ...
Zhijia Li +5 more
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Progress and challenges towards additive manufacturing of SiC ceramic
Journal of Advanced Ceramics, 2021 Silicon carbide (SiC) ceramic and related materials are widely used in various military and engineering fields. The emergence of additive manufacturing (AM) technologies provides a new approach for the fabrication of SiC ceramic products.
Rujie He +6 more
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Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
bioRxiv, 2020 The recent emergence of a novel coronavirus associated with an ongoing outbreak of pneumonia (Covid-2019) resulted in infections of more than 72,000 people and claimed over 1,800 lives.
A. Walls +5 more
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