Results 291 to 297 of about 3,626,748 (297)

EPC syntheses and structure–activity relationships of hypoglycaemic semicyclic amidines

European Journal of Medicinal Chemistry, 2000
A series of homochiral sterically hindered mono- and bicyclic amidines was prepared as hypoglycaemic agents by lethargic reaction of O-methylcaprolactim and 3-ethoxy-2-azabicyclo[2.2.2]oct-2-ene, respectively, with homochiral cis-2-substituted cyclopentane amines provided by asymmetrical reductive amination of racemic 2-substituted cyclopentanones. All
S, Hartmann, S, Ullrich, C, Hupfer, A W, Frahm   +3 more
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Anticoagulant sulfated polysaccharides: Part I. Synthesis and structure–activity relationships of new pullulan sulfates

Carbohydrate Polymers, 2002
In order to develop new anticoagulants as potential heparin alternatives, two pullulans with different molecular weight (MW) were used as starting polymers for the partial synthesis of a structurally new class of sulfated polysaccharides. Sulfation of these linear α-1,4-/1,6-glucans was carried out by a method with a SO3–pyridine complex in DMF, which ...
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Uniform-length molecular descriptors for quantitative structure–property relationships (QSPR) and quantitative structure–activity relationships (QSAR): classification studies and similarity searching

TrAC Trends in Analytical Chemistry, 1999
Abstract Molecular descriptors represent important tools for predicting properties of chemicals, for classifying chemical structures, and for seeking similarities among them. A class of molecular descriptors is described which views a molecule as a whole, and leads to codes of uniform length, irrespective of the size of the molecule.
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