Results 221 to 230 of about 3,625,864 (333)

Novel Synthesis of the Antifungal Cyclic Lipopeptide Iturin A and Its Fluorinated Analog for Structure-Activity Relationship Studies. [PDF]

Chemistry
Karamanis P, Kiernan M, Muldoon J, Doyle F, Evans P, Murphy CD, Rubini M.   +6 more
europepmc   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

A Review of Quantitative Structure-Activity Relationship (QSAR) Models to Predict Thyroid Hormone System Disruption by Chemical Substances. [PDF]

Toxics
Evangelista M, Papa E.
europepmc   +1 more source

Total Synthesis of Mandelalide A and Synthesis of (–)‐Zampanolide Analogs for Structure‐Activity Relationship Studies

, 2016
Tobias Michael Brà ⁄ tsch
openalex   +2 more sources

Engineering the Link: From Genome Interaction Maps to Functional Insight

Advanced Biology, EarlyView.
Advances in chromosome conformation capture have revealed the genome's 3D organization, yet its causal impact on gene regulation remains elusive. This review highlights emerging genome‐engineering tools ‐ zinc fingers, TALEs, and CRISPR‐Cas9 ‐ that enable targeted manipulation of chromatin loops to dissect structure–function relationships. It discusses
Frido Petersen, Simon Westermann, Valeriia Smialkovska, Jan Mathony, Angelika Feldmann, Dominik Niopek   +5 more
wiley   +1 more source

Structure-Activity Relationship Studies of Emtricitabine Prodrugs toward Long-Acting Antiretroviral Formulations. [PDF]

ACS Omega
Al-Khouja A, Henriquez S, Hobson JJ, White JA, Flexner C, Owen A, Rannard SP, Freel Meyers CL.   +7 more
europepmc   +1 more source

ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors

, 2018
Upul K. Bandarage, Jingrong Cao, Jon H. Come, John J. Court, Huai Gao, Marc Jacobs, Craig Marhefka, Suganthi Nanthakumar, Jeremy Green   +8 more
openalex   +1 more source

Bistable Mechanisms 3D Printing for Mechanically Programmable Vibration Control

Advanced Engineering Materials, EarlyView.
This work introduces a 3D‐printed bistable mechanism integrated into tuned mass dampers (TMDs) for mechanically adaptive passive vibration suppression. Through optimized geometry, the bistable design provides adaptable vibration reduction across a broad range of scenarios, achieving effective vibration mitigation without complex controls or external ...
Ali Zolfagharian, Frédéric Demoly, Mohammad Lakhi, Bernard Rolfe, Mahdi Bodaghi   +4 more
wiley   +1 more source

Modeling and Interpretability Study of the Structure-Activity Relationship for Multigeneration EGFR Inhibitors. [PDF]

ACS Omega
Sun Z, Huo D, Guo J, Yan A.
europepmc   +1 more source

Synthesis and Biological Activities of Neoechinulin A Derivatives: New Aspects of Structure-Activity Relationships for Neoechinulin A

, 2008
Kouji Kuramochi, Kensuke Ohnishi, Satoshi Fujieda, Mitsuhiro Nakajima, Yoshihiko Saitoh, Nobuo Watanabe, Toshifumi Takeuchi, Atsuo Nakazaki, Fumio Sugawara, Takao Arai, Susumu Kobayashi   +10 more
openalex   +2 more sources