Results 301 to 310 of about 3,625,864 (333)

Structure–activity relationships in nitrothiophenes

Bioorganic & Medicinal Chemistry, 2006
The structure and electronic properties of a series of biologically active 2-nitrothiophenes (1) have been calculated using both semi-empirical and ab initio molecular orbital methods. Multi-linear regression analysis suggests that there is a reasonable correlation between the experimental activity of the derivatives against either Escherichia coli or ...
John O, Morley, Thomas P, Matthews
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Structure-activity relationships of chemokines

Journal of Leukocyte Biology, 1995
Abstract Structural analysis of chemokines has revealed that the α/β structural-fold is highly conserved among both the CXC and CC chemokine classes. Although dimerization and aggregation is often observed, the chemokines function as monomers.
I, Clark-Lewis, K S, Kim, K, Rajarathnam, J H, Gong, B, Dewald, B, Moser, M, Baggiolini, B D, Sykes   +7 more
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Cytochalasins: Structure-activity relationships

Phytochemistry, 1990
Abstract Seven cytochalasins, 17- O -acetylcytochalasin A and two derivatives of cytochalasin B were assayed for Pseudomonas syringae , Bacillus megaterium , and for Geotrichum candidum . Their ability to inhibit the growth of tomato seedlings and their toxicity to brine shrimp (% larvae mortality were also investigated.
Bottalico A, Capasso R, Evidente A, Randazzo G, Vurro M   +4 more
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Structure−Activity Relationships of the Didemnins

Journal of Medicinal Chemistry, 1996
Bioactivities of 42 didemnin congeners, either isolated from the marine tunicates Trididemnun solidum and Aplidium albicans or prepared synthetically and semisynthetically, have been compared. The growth inhibition of various murine and human tumor cells and plaque reduction of HSV-1 and VSV grown on cultured mammalian cells were used to assess ...
R, Sakai, K L, Rinehart, V, Kishore, B, Kundu, G, Faircloth, J B, Gloer, J R, Carney, M, Namikoshi, F, Sun, R G, Hughes, D, García Grávalos, T G, de Quesada, G R, Wilson, R M, Heid   +13 more
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Structure-activity relationships of adrenocorticotropin

Pharmacology & Therapeutics. Part B: General and Systematic Pharmacology, 1975
Since the entire amino acid sequence of the adrenocort icotropin (adrenocort icotropic hormone, ACTH) from pig pituitaries was proposed (Bell, 1954; Shepherd et al., 1956b), a number of f ragments and analogues of A C T H have been synthesized and submitted to biological characterization.
H, Otsuka, K, Inouye
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Structure activity relationships of spiramycins

Journal of Antimicrobial Chemotherapy, 1985
Sixty-six derivatives of spiramycin I and neospiramycin I were synthesized and evaluated by four parameters, MIC, affinity to ribosomes (ID50), therapeutic effect in mice and retention time in HPLC. Among the derivatives, 3,3'',4''-tri-O-propionyl- and 3,4''-di-O-acetyl-3''-O-butyrylspiramycin I showed the highest therapeutic effect which was superior ...
S, Omura, H, Sano, T, Sunazuka
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Epibatidine Structure—Activity Relationships

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
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Quantitative structure-activity relationships

1979
Designing of biologically active molecules on a rational basis is of utmost importance to medicinal chemists. Until about the late 1950’s most of the structure-activity correlations were emperical and qualitative. Although attempts have been made to apply quantitative methods to biological activity since last century, a major effort in this field has ...
A K, Saxena, S, Ram
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Fuzzy structure-activity relationships

SAR and QSAR in Environmental Research, 2003
While quantitative structure-activity relationships attempt to predict the numerical value of the activities, it is found that statistically good predictors do not always do a good job of qualitatively determining the activity. This study shows how Fuzzy classifiers can be used to generate Fuzzy structure-activity relationships which can more ...
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Structure-Activity Relationships in Glucocorticoids

1979
Meaningful answers to the question of the relationship between glucocorticoid structure and activity have emerged. Structural change has predictable effects on susceptibility to the action of metabolizing enzymes, on receptor affinity, and on intrinsic activity. These effects are, in principle, amenable to mathematical modeling techniques.
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