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Structure-Activity Relationships in Coumermycins
1972Publisher Summary This chapter focuses on the structure–activity relationships in coumermycins. The naturally occurring coumermycins are produced in fermentation broths of several species of Streptomyces . Degradative studies at Bristol–Banyu Research Institute established the structures of coumermycins A 1 and A 2 .
J C, Godfrey, K E, Price
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Structure-Activity Relationships
2019In-depth analysis of the structure of the drug and its subsequent modification yield drugs with high affinity and increased receptor specificity with an improved pharmacokinetic profile. Modification of the parent molecule of catecholamines, called β-phenyl-ethyl-amine, provided orally active adrenergic bronchodilators, long-acting β2-adrenergic ...
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Structure-Activity Relationships
1971One of the most intriguing developments in the field of narcotic analgesics has been the discovery of the narcotic antagonists.(1–3) These compounds, which reverse or prevent most of the pharmacological actions of the narcotic analgesics, may have analgesic activity themselves. This finding was uncovered serendipitously in the clinic with nalorphine(4)
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Structure-Activity Relationships
1999Estrogens and antiestrogens are understood to exert their hormonal action after binding to the estrogen receptor (ER), a member of the nuclear receptor superfamily. Until recently, the knowledge of the shape of the full-length ER and the structure of the hormone-binding domain has been rather vague, due to the lack of cristallographie data. Information
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Structure-Activity Relationships in Chemoreception
Trends in Biochemical Sciences, 1976openaire +1 more source