Results 221 to 230 of about 33,351,014 (255)

Structure-Based Virtual Screening and In Silico Evaluation of Marine Algae Metabolites as Potential α-Glucosidase Inhibitors for Antidiabetic Drug Discovery. [PDF]

Pharmaceuticals (Basel)
Rossafi B, Abchir O, Guerguer F, Abass KS, Yamari I, El Kouali M, Samadi A, Chtita S.   +7 more
europepmc   +1 more source

A Bioinspired, Multimodal Soft Tactile Skin with Task‐Adaptive Perception for Intelligent Robotic Manipulation

Advanced Science, EarlyView.
Perception in robotic manipulation improves through the cooperative and complementary operation of biologically inspired multimodal tactile sensors. Receptor‐specific contribution analysis identifies which sensing modalities are required for specific tactile tasks.
Yu‐Jin Lee, Hyeonung Kang, Ju Yeon Woo, Daekyum Kim, Chang‐Soo Han   +4 more
wiley   +1 more source

Adjuvant activity of a small molecule TLR4 agonist discovered via structure-based virtual screening. [PDF]

Commun Biol
Kadivella M, Varma VP, Cp J, Kavela S, Azam S, Faisal SM.   +5 more
europepmc   +1 more source

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

Structure-based virtual screening aids the identification of glycosyltransferases in the biosynthesis of salidroside. [PDF]

Plant Biotechnol J
Yao Y, Chen F, Wu C, Chang X, Cheng W, Wang Q, Deng Z, Liu T, Lu L.   +8 more
europepmc   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

MZF1 Inhibits TGFβ‐1/SMAD Signaling by Transcriptionally Activating SnoN to Augment Tumorigenic Potential in Colon Cancer

Advanced Science, EarlyView.
This study identifies MZF1 as a core regulator of colon cancer via SnoN‐mediated TGF‐β suppression, proposes 10Panx Acetate as a targeted inhibitor, and validates MZF1/SnoN as prognostic markers for aggressive disease. ABSTRACT Colon cancer progression is associated with transcriptional and signaling abnormalities.
Siqi Sheng, Mengxi Huang, Yiting Wang, Hongyu Wang, Haimei Feng, Xiaoming Bai, Jie Chen, Ke Xu, Xiaoyuan Chu, Zengjie Lei   +9 more
wiley   +1 more source

Discovery of Two GSK3β Inhibitors from <i>Sophora flavescens</i> Ait. using Structure-based Virtual Screening and Bioactivity Evaluation. [PDF]

Curr Comput Aided Drug Des
Pan D, Zeng Y, Jiang D, Zhang Y, Wu M, Huang Y, Han M, Jin X.   +7 more
europepmc   +1 more source

Drug Repurposing for AML: Structure-Based Virtual Screening and Molecular Simulations of FDA-Approved Compounds with Polypharmacological Potential. [PDF]

Biomedicines
Abdelsayed M, Boulaamane Y.
europepmc   +1 more source

Identification of FDA-Approved Drugs as Potential Inhibitors of WEE2: Structure-Based Virtual Screening and Molecular Dynamics with Perspectives for Machine Learning-Assisted Prioritization. [PDF]

Life (Basel)
Ali S, Elasbali AM, Alzahrani W, Mohammad T, Hassan MI, Zhou T.   +5 more
europepmc   +1 more source