Results 41 to 50 of about 33,351,014 (255)

Discovery of Tyrosinase Inhibitors: Structure-Based Virtual Screening and Biological Evaluation

Pharmaceutical Fronts, 2022
Tyrosinase (EC 1.14.18.1) plays an indispensable role in the rate-limiting steps of melanin biosynthesis, and its uncontrolled activity may result in various diseases, such as albinism, melanoma, freckles, etc.
Guan Wang, Jin Li, Xiao-Li Pan, Fa-Qian Bu, Yu-Meng Zhu, Ao-Xue Wang, Liang Ouyang   +6 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation

Journal of Enzyme Inhibition and Medicinal Chemistry
Dual-specificity tyrosine-regulated kinase 1 A (DYRK1A) is crucial in neurogenesis, synaptogenesis, and neuronal functions. Its dysregulation is linked to neurodegenerative disorders like Down syndrome and Alzheimer’s disease. Although the development of
Huang-Ju Tu, Min-Wu Chao, Cheng-Chung Lee, Chao-Shiang Peng, Yi-Wen Wu, Tony Eight Lin, Yu-Wei Chang, Shih-Chung Yen, Kai-Cheng Hsu, Shiow-Lin Pan, Wei-Chun HuangFu   +10 more
doaj   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Kernel learning for ligand-based virtual screening: discovery of a new PPARgamma agonist [PDF]

, 2010
Poster presentation at 5th German Conference on Cheminformatics: 23. CIC-Workshop Goslar, Germany. 8-10 November 2009 We demonstrate the theoretical and practical application of modern kernel-based machine learning methods to ligand-based virtual ...
Rau O, Zettl H, Gisbert Schneider, R Steri, Schubert-Zsilavecz, Manfred (Prof. Dr.), M Schubert-Zsilavecz, Matthias Rupp, Ewgenij Proschak, Schroeter, Timon, H Zettl, Proschak, Ewgenij, Rau, Oliver, Schroeter T, K Hansen, T Schroeter, O Rau, Rupp, Matthias, Rupp Matthias, K-R Müller, Proschak Ewgenij, Müller K-R, Zettl, Heiko, Steri R, Hansen, Katja, Müller, Klaus-Robert, Hansen K, Schneider, Gisbert (Prof. Dr.), Steri, Ramona, Schubert-Zsilavecz M, Schneider Gisbert   +29 more
core   +1 more source

Discovery of novel IDH1-R132C inhibitors through structure-based virtual screening

Frontiers in Pharmacology, 2022
Isocitrate dehydrogenase (IDH) belongs to a family of enzymes involved in glycometabolism. It is found in many living organisms and is one of the most mutated metabolic enzymes.
Chujiao Hu, Chujiao Hu, Chujiao Hu, Chujiao Hu, Chujiao Hu, Zhirui Zeng, Zhirui Zeng, Dan Ma, Dan Ma, Zhixin Yin, Shanshan Zhao, Tengxiang Chen, Tengxiang Chen, Lei Tang, Lei Tang, Shi Zuo, Shi Zuo   +16 more
doaj   +1 more source

A nationwide student survey on biochemistry learning resources in Italy

FEBS Open Bio, EarlyView.
We conducted a survey among Italian university students to investigate their preferred study materials for biochemistry. We then analyzed the collected data to identify these materials. This information may be valuable to the Biochemistry educational community. The graphical abstract was created with Claude (Opus 5.5; Anthropic, 2026).
Anna Marabotti, Ivano Eberini, Maria Luisa Genova, Francesca Mensitieri, Francesco Malatesta   +4 more
wiley   +1 more source

Implementing relevance feedback in ligand-based virtual screening using bayesian inference network [PDF]

, 2011
Recently, the use of the Bayesian network as an alternative to existing tools for similarity-based virtual screening has received noticeable attention from researchers in the chemoinformatics field.
Naomie Salim, Abdo, Ammar, Ammar Abdo, Salim, Naomie, Ahmed, Ali, Ali Ahmed   +5 more
core   +1 more source

Optimal ligand descriptor for pocket recognition based on the Beta-shape.

PLoS ONE, 2015
Structure-based virtual screening is one of the most important and common computational methods for the identification of predicted hit at the beginning of drug discovery.
Jae-Kwan Kim, Chung-In Won, Jehyun Cha, Kichun Lee, Deok-Soo Kim   +4 more
doaj   +1 more source