GOBeacon: An ensemble model for protein function prediction enhanced by contrastive learning. [PDF]
Protein SciLin W, Miller D, Gu Z, Orengo C.
europepmc +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Computational and experimental assessment of key interdomain residues controlling the fold-switch of RfaH. [PDF]
Protein SciTabilo-Agurto C +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
Research on the reliability of the overall structure of submerged radial steel gate. [PDF]
PLoS OneYu Y +5 more
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The crystal structure of dimethyl acetylene at –50° C
, 1955 E. Pignataro, B. Post
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EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Tokenized and continuous embedding compressions of protein sequence and structure. [PDF]
Patterns (N Y)Lu AX +7 more
europepmc +1 more source
The Structure of Man. An Index to His Past History . By Dr. R. Wiedersheim, Professor in the University of Freiburg in Baden. Translated by H. and M. Bernard. The Translation edited and annotated and a Preface written by G. B. Howes, F. L. S., Professor of Zoology, Royal College of Science, London. With 105 Figures in the Text. Macmillan & Co., London and New York. Price $2.60. [PDF]
, 1895 Harrison Allen
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Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source