Results 151 to 160 of about 9,663,658 (313)
, 1959 Report containing articles, manuscripts, and tabulations of recorded spectra created by the Spectroscopic Laboratory of the University of ...
University of Chicago. Laboratory of Molecular Structure and Spectra.
core
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
, 1962 Report containing articles, manuscripts, and tabulations of recorded spectra created by the Spectroscopic Laboratory of the University of ...
University of Chicago. Laboratory of Molecular Structure and Spectra.
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
, 1961 Report containing articles, manuscripts, and tabulations of recorded spectra created by the Spectroscopic Laboratory of the University of ...
University of Chicago. Laboratory of Molecular Structure and Spectra.
core
When can AlphaFold predict the oligomeric states of proteins? [PDF]
Protein SciLin Y, Wallis C, Corry B.
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Complementarity of structure ensembles in protein-protein binding
, 2004 Protein-protein association is often accompanied by changes in receptor and ligand structure. This interplay between protein flexibility and protein-protein recognition is currently the largest obstacle both to our understanding of and to the reliable ...
Grünberg, Raik +2 more
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source