Results 181 to 190 of about 9,663,658 (313)

Mechanical Performance-Enhanced Parabolic Curved-Beam Lattice Structures: Multi-Objective Optimization and Theoretical Modeling. [PDF]

Materials (Basel)
Min D, Wang Q, Yu L, Jin Z, Zhong R.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Predicting unknown binding sites for transition-metal-based compounds in proteins. [PDF]

PLoS One
Levy A, Rothlisberger U.
europepmc   +1 more source

An assessment of the cytochrome P450 2-hydroxyisoflavanone synthase (2-HIS) crystal structure. [PDF]

Commun Biol
Poulos TL.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Unveiling the roles of device structure and driving frequency in mitigating crosstalk effects in nanopixel light-emitting displays. [PDF]

Microsyst Nanoeng
Li W, Zhang S, Zhou X, Zhang Y, Guo T, Wu C.   +5 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

26 Towards an HIV functional cure with CAR-T cells: elucidating mechanisms underlying the extremely high potency of bispecific anti-HIV CARs designed for optimal activity and minimal immunogenicity

Journal of Virus Eradication, 2017
M.H. Ghanem, B. Dey, S. Bolivar-Wagers, D. Vargas-Inchaustegui, V. Bundoc, D.T. Danielson, D. Elias, A. Hajduczki, E.A. Berger   +8 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Limitations of the refolding pipeline for de novo protein design. [PDF]

Protein Sci
Korbeld KT, Viliuga V, Fürst MJLJ.
europepmc   +1 more source