Results 211 to 220 of about 9,692,539 (313)

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Lysozyme revisited: evaluating models of a reference protein in structural biology. [PDF]

Curr Res Struct Biol
Wlodawer A, Rubach P, Dauter Z, Dec W, Brzezinski D, Jaskolski M, Minor W.   +6 more
europepmc   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Structure-function coupling of large-scale cortical networks across the lifespan is spectrally specific. [PDF]

Commun Biol
Picci G, Rempe MP, Petro NM, Son JJ, Casagrande CC, Ott LR, Penhale SH, Embury CM, Schantell M, Johnson HJ, Okelberry HJ, Willett MP, Wang YP, Stephen JM, Calhoun VD, Wiesman AI, Kurz MJ, Heinrichs-Graham E, Wilson TW.   +18 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Morphological changes in smectic liquid crystal microstructures.

Soft Matter
Sato D, Sumino Y, Yamamoto T, Muševič I, Takenaka Y.   +4 more
europepmc   +1 more source

Predicting unknown binding sites for transition-metal-based compounds in proteins. [PDF]

PLoS One
Levy A, Rothlisberger U.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Water adsorption on a model silicate surface: wollastonite (100).

Nanoscale
Lezuo L, Conti A, Hoheneder A, Vaníčková E, Aloi DA, Abart R, Mittendorfer F, Schmid M, Diebold U, Franceschi G.   +9 more
europepmc   +1 more source