Results 111 to 120 of about 1,019,415 (265)

The Structure-Activity Relationship and Anticoagulation Mechanism of Polyglycerol Sulfates of Different Architectures. [PDF]

Biomacromolecules
Krage C, Weinhart M, Lai BFL, Stöshel A, Achazi K, Kizhakkedathu JN, Haag R.   +6 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Structure-Activity Relationship of Cyanine Dyes in Relation to the Hepatic Uptake and Excretion. [PDF]

Chembiochem
Berehova NS, de Bock ELJ, van Meerbeek MP, Naar CM, van den Eng T, Bouw NA, Buckle T, van Leeuwen FWB.   +7 more
europepmc   +1 more source

Competition and Innovation: An Inverted U Relationship [PDF]

This paper investigates the relationship between product market competition (PMC) and innovation. A growth model is developed in which competition may increase the incremental profit from innovating; on the other hand, competition may also reduce ...
Philippe Aghion, Nicholas Bloom, Richard Blundell, Rachel Griffith, Peter Howitt   +4 more
core  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Structure-Activity Relationship and Crystallographic Study of New Monobactams. [PDF]

J Med Chem
Kavaš V, Contreras-Martel C, Pajk S, Knez D, Martins A, Gould TA, Roper DI, Zdovc I, Dessen A, Hrast Rambaher M, Gobec S.   +10 more
europepmc   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Dihydrosanguinarine: A Review of Its Pharmacology, Structure-Activity Relationship, Toxicity, Pharmacokinetics, and Clinical Prospects. [PDF]

Int J Mol Sci
Yin X, Cao Y, Fang C, Zhang C, Yang J, Yu M, Cheng G, Yang L.   +7 more
europepmc   +1 more source

Genetic algorithms: A tool for quantitative structure-activity relationship analyses.

, 1996
Genetic algorithms: A tool for quantitative structure-activity relationship ...
Hitesh C. Patel (7967996)
core  

Structure-activity relationship study of splicing modulators on Hsh155/SF3B1 through chemical synthesis and yeast genetics

Meayamycins are synthetic analogs of the natural product FR901464 and exhibit potent anticancer activity against human cancers. They bind SF3B1 and PHF5A, components of the human spliceosome, and alter pre-mRNA splicing.
John, Schmitz, Aaron, Hoskins, Jacob, Beard, Kazunori, Koide, Sierra, Love   +4 more
core   +1 more source