Results 211 to 220 of about 16,673,842 (253)
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Structure activity relationships of spiramycins
Journal of Antimicrobial Chemotherapy, 1985Sixty-six derivatives of spiramycin I and neospiramycin I were synthesized and evaluated by four parameters, MIC, affinity to ribosomes (ID50), therapeutic effect in mice and retention time in HPLC. Among the derivatives, 3,3'',4''-tri-O-propionyl- and 3,4''-di-O-acetyl-3''-O-butyrylspiramycin I showed the highest therapeutic effect which was superior ...
S, Omura, H, Sano, T, Sunazuka
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Structure-Activity Relationships in Glucocorticoids
1979Meaningful answers to the question of the relationship between glucocorticoid structure and activity have emerged. Structural change has predictable effects on susceptibility to the action of metabolizing enzymes, on receptor affinity, and on intrinsic activity. These effects are, in principle, amenable to mathematical modeling techniques.
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Statistical Analysis of Structure-Activity Relationships
Toxicological Sciences, 1983The relationship between organic structure and biological activity (toxicity) is examined by statistically comparing concentration-response regression lines among structurally related compounds. Response data from acute toxicity tests are initially transformed to the logistic function while concentration data are transformed to the logarithm base 10 ...
K L, Daniels +3 more
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Exploiting Structure–Activity Relationships in Docking
Journal of Chemical Information and Modeling, 2008From the perspective of 2D chemical descriptors, error in docking activity predictions is separated into noise and systematic components. This error framework explains how fitting docking scores to a 2D-QSAR equation often improves accuracy as well as its logical limits.
David C. Sullivan, Eric J. Martin
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The Relationship between Structure and Activity of Taurolin
Journal of Applied Bacteriology, 1980Taurolin [Bis(1,1‐dioxo‐perhydro‐1,2,4 thiadiazinyl‐4)methane] is an antimicrobial compound formed by the condensation of two molecules of taurine with three of formaldehyde. It has been suggested that it releases formaldehyde in contact with bacteria. Evidence from TLC, HPLC and NMR spectroscopy indicates that taurolin is mostly hydrolysed in aqueous ...
Myers, E. +3 more
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Structure-Activity Relationships in Coumermycins
1972Publisher Summary This chapter focuses on the structure–activity relationships in coumermycins. The naturally occurring coumermycins are produced in fermentation broths of several species of Streptomyces . Degradative studies at Bristol–Banyu Research Institute established the structures of coumermycins A 1 and A 2 .
J C, Godfrey, K E, Price
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Structure-Activity Relationships
2019In-depth analysis of the structure of the drug and its subsequent modification yield drugs with high affinity and increased receptor specificity with an improved pharmacokinetic profile. Modification of the parent molecule of catecholamines, called β-phenyl-ethyl-amine, provided orally active adrenergic bronchodilators, long-acting β2-adrenergic ...
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American Cancer Society nutrition and physical activity guideline for cancer survivors
Ca-A Cancer Journal for Clinicians, 2022Colleen Spees +2 more
exaly
Structure-Activity Relationships
1971One of the most intriguing developments in the field of narcotic analgesics has been the discovery of the narcotic antagonists.(1–3) These compounds, which reverse or prevent most of the pharmacological actions of the narcotic analgesics, may have analgesic activity themselves. This finding was uncovered serendipitously in the clinic with nalorphine(4)
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