Results 91 to 100 of about 5,072,023 (302)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Circuit complexity of quantum access models for encoding classical data

npj Quantum Information
How to efficiently encode classical data is a fundamental task in quantum computing. While many existing works treat classical data encoding as a black box in oracle-based quantum algorithms, their explicit constructions are crucial for the efficiency of
Xiao-Ming Zhang, Xiao Yuan
doaj   +1 more source

The Hofstadter Energy Spectrum for an Interacting 2DEG

, 1995
We study the effects of the Coulomb interactions between electrons on the Hofstadter butterfly, which characterizes the subband structure of the Landau levels of a two-dimensional electron gas in a perpendicular homogeneous magnetic field and a periodic ...
Ferrari, Gerhardts, Kühn, Petschel, Pfannkuche, Rolf R. Gerhardts, Silberbauer, Vidar Gudmundsson, Weiss   +8 more
core   +2 more sources

Neurotrophins: structural relatedness and receptor interactions

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1991
Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are structurally related proteins that allow the survival of specific populations of embryonic vertebrate neurons. The primary structure of these neurotrophins, deduced from their nucleotide sequences, indicates that all three are synthesized in the form of ...
Rodríguez-Tebar, Alfredo, Dechant, G., Barde, Yves Alain   +2 more
openaire   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Weak self-interactions of globular proteins studied by small-angle X-ray scattering and structure-based modeling

, 2014
We investigate protein-protein interactions in solution by small-angle X-ray scattering (SAXS) and theoretical modeling. The structure factor for solutions of bovine pancreatic trypsin inhibitor (BPTI), myoglobin (Mb), and intestinal fatty acid-binding ...
Halle, Bertil, Kaieda, Shuji, Lund, Mikael, Plivelic, Tomás S.   +3 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Polarization-insensitive narrowband reflective wavefront manipulation through all-dielectric anisotropic subwavelength structures

iScience
Summary: Local metasurfaces provide high flexibility in shaping wavefronts but suffer from poor frequency selectivity. Here, we numerically present a reflective all-dielectric metasurface platform achieving simultaneous local phase control and spectral ...
Meiyan Pan, Yanxin Lu, Jintao Wang, Yihang Chen   +3 more
doaj   +1 more source

Sensitivities and correlations of nuclear structure observables emerging from chiral interactions

, 2016
Starting from a set of different two- and three-nucleon interactions from chiral effective field theory, we use the importance-truncated no-core shell model for ab initio calculations of excitation energies as well as electric quadrupole (E2) and ...
Calci, Angelo, Roth, Robert
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source