Results 191 to 200 of about 32,189,684 (346)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

SIRT1 Inhibits T-cell Infiltration and Tertiary Lymphoid Structure Formation to Promote Radioimmunotherapy Resistance. [PDF]

Cancer Res
Shi Y, Wu ZF, Liu S, Wan T, Luo R, Liu H, Zeng Z, Li W, Liang Z, Xiong L, Luo S, Yuan Y, Huang L, Kang L.   +13 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Dynamic progression of ectopic lymphoid structure formation in lacrimal glands of a Sjögren's disease murine model. [PDF]

Front Immunol
Abdelhamid S, Ramirez AV, Aksan E, Demianova EA, de Paiva CS, Edman MC, MacKay JA, Hamm-Alvarez SF.   +7 more
europepmc   +1 more source

Secteur de formation 2 : agriculture et pêches

, 2009
Titre de l'écran-titre (visionné le 9 juillet 2009)"Secteur de formation 2 : agriculture et pêches"Version électronique d'un document imprimé publié en ...
Fons, Jean-Pierre, Québec (Province). Formation professionnelle et technique et formation continue. Direction générale de la formation professionnelle et technique, Hallé, Jean-Claude, Beaussier, Dominique   +3 more
core  

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Characterization of cancer-associated fibroblast populations that promote tertiary lymphoid structure formation in murine melanoma tumors. [PDF]

Front Immunol
Barnes R, Cummings K, Perusina Lanfranca M, Rodriguez AB, Stasiak K, Ludewig B, Dolatshahi S, Engelhard VH.   +7 more
europepmc   +1 more source

Convexity and Complementarity in Network Formation: Implications for the Structure of Pairwise Stable Networks [PDF]

This paper studies the properties of convexity (concavity) and strategic complements (substitutes) in network formation and the implications for the structure of pairwise stable networks. First, different definitions of convexity (concavity) in own links
Tim Hellmann
core  

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Mechanism of self-protected structure formation in titanium alloy radiation rods during ultrasonic casting. [PDF]

Ultrason Sonochem
Cao H, Dong F, Wu H, Liu Z.
europepmc   +1 more source