Results 91 to 100 of about 5,952,869 (294)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Standing genetic variation and introgression shape the cryptic radiation of Aquilegia in the mountains of Southwest China

Communications Biology
Cryptic diversity in evolutionary radiation offers an excellent system for investigating the intricacies of evolutionary progress. Understanding the evolution of cryptic diversity is imperative for unraveling the hidden complexities of biodiversity ...
Jun-Chu Peng, Ziwen He, Zhi-Qiang Zhang
doaj   +1 more source

Small Structural Differences in Proline-Rich Decapeptides Have Specific Effects on Oxidative Stress-Induced Neurotoxicity and L-Arginine Generation by Arginosuccinate Synthase

Pharmaceuticals
Introduction. The proline-rich decapeptide 10c (Bj-PRO-10c; ENWPHPQIPP) from the Bothrops jararaca snake modulates argininosuccinate synthetase (AsS) activity to stimulate L-arginine metabolite production and neuroprotection in the SH-SY5Y cell line. The
Carlos Alberto-Silva, Brenda Rufino da Silva, Julio Cezar Araujo da Silva, Felipe Assumpção da Cunha e Silva, Roberto Tadashi Kodama, Wilmar Dias da Silva, Maricilia Silva Costa, Fernanda Calheta Vieira Portaro   +7 more
doaj   +1 more source

The Structure and Functions of Language

Studies in Logic, Grammar and Rhetoric, 2014
This paper will discuss the nature of language. I find the present state of the subject, the Philosophy of Language, and the present state of Lin- guistics to be both, for different reasons, unsatisfactory.
Searle John R.
doaj   +1 more source

Casein chemistry—structure, functions, and applications [PDF]

Exploration of Foods and Foodomics
The health benefits of milk have been acknowledged throughout human history, with scientific research over the past 50 years elucidating its nutritional composition and functional benefits.
Edward P. C. Lai, Apollinaire Tsopmo
doaj   +1 more source

Structure and Function

, 1996
to appear in Proceed.
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Nucleon Structure Functions from the NJL-Model Chiral Soliton

, 2019
We present numerical simulations for unpolarized and polarized structure functions in a chiral soliton model. The soliton is constructed self-consistently from quark fields from which the structure functions are extracted.
Takyi, I., Weigel, H.
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The utility of some metrics in developing a landscape diagnosis. Case study: Botoroaga commune, Teleorman County, Romania. [PDF]

Cinq Continents, 2017
The major concern of this paper is represented by the capacity of rural areas to support residential sprawl, feature which generates strong implications on the structure and functions of the adjacent landscape.
Mihai Mustățea
doaj