Structure and Functions of Ubquitin System
Eurasian Journal of Medicine, 2019 -
Ahmet Kızıltunç, Yaşar Nuri Şahin
doaj
Phylogeny, Structure, Functions, and Role of AIRE in the Formation of T-Cell Subsets. [PDF]
Cells, 2022 Shevyrev D +3 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
RBM10: Structure, functions, and associated diseases. [PDF]
Gene, 2021 Inoue A.
europepmc +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
BipD of Burkholderia pseudomallei: Structure, Functions, and Detection Methods. [PDF]
Microorganisms, 2021 Selvam K +4 more
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Echinoderms Metabolites: Structure, Functions, and Biomedical Perspectives. [PDF]
Mar Drugs, 2021 Kalinin VI.
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
AAA ATPases as therapeutic targets: Structure, functions, and small-molecule inhibitors. [PDF]
Eur J Med Chem, 2021 Zhang G, Li S, Cheng KW, Chou TF.
europepmc +1 more source