Results 121 to 130 of about 3,832,797 (315)
Using a Stack Decoder for Structured Search
, 2013 We describe a novel and flexible method that translates free-text queries to structured queries for filling out web forms. This can benefit searching in web databases which only allow access to their information through complex web forms. We introduce boosting and discounting heuristics, and use the constraints imposed by a web form to find a solution ...
Kien-Tsoi T. E. Tjin-Kam-Jet +2 more
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Self-Organizing Maps and the US Urban Spatial Structure [PDF]
This article considers urban spatial structure in US cities using a multi- dimensional approach. We select six key variables (commuting costs, den- sity, employment dispersion/concentration, land-use mix, polycentricity and size) from the urban ...
Daniel Arribas-Bel, Charles R. Schmidt
core
Lexical inferencing procedures in L3 Italian [PDF]
, 2014 This study is aimed at investigating and describing the different procedures of foreign language learners of Italian when they infer the meaning of unknown words in a written authentic text.
Smidfelt, Linda,, Lund University.
core
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
On Filtering in Markovian Term Structure Models (An Approximation Approach) [PDF]
We study a nonlinear filtering problem to estimate, on the basis of noisy observations of forward rates, the market price of interest rate risk as well as the parameters in a particular term structure model within the Heath-Jarrow-Morton family.
Sara Pasquali +2 more
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Computers and the Wage Structure [PDF]
A leading explanation for the rapid growth in U.S. wage inequality in the last twenty years, consistent with both human capital and postindustrial theories, is that advanced technology has increased job skill requirements and reduced the demand for less ...
Michael J. Handel
core +3 more sources
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source