Results 41 to 50 of about 492,047 (263)

Local Translation in Growth Cones and Presynapses, Two Axonal Compartments for Local Neuronal Functions

Biomolecules, 2020
During neural development, growth cones, very motile compartments of tips of axons, lead axonal extension to the correct targets. Subsequently, presynapses, another axonal compartment with vigorous trafficking of synaptic vesicles, emerge to form ...
Yukio Sasaki
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

USING THE PRINCIPLES OF TACTICAL URBANISM IN THE RENOVATION OF THE ESPLANADE IN THE CITY OF PERM

Архитектон, 2022
The article presents some economic and analytical prerequisites and substantiation of the planning concept for the Explanada territory of Perm. Specific design solutions for the renovation of the city esplanade are considered and substantiated in more ...
Shchipalkin Victor P., Shchipalkina Tatyana V., Kuryakova Natalia B., Raizikh Ekaterina V.   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Exploration of the changing structure of cities: Challenges for temporal city models [PDF]

2015 Digital Heritage, 2015
The ALARIC project (Incremental Urban Change Research Project) is dedicated to the production of geo-historical information concerning two formerly industrial cities of the Lyon-Saint-Etienne region (19 th and 20 th century). The exploration of the incremental nature of urban change implies identifying when certain historical processes took place, such
Clementine Perinaud, Georges Gay, Gilles Gesquière   +2 more
openaire   +2 more sources

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Influence of Wrap-Around Facing Types on the Seismic Response of Reinforced Loess Slopes: A Comparative Study of Two Seismic Waves

Buildings
To promote the application of wrap-around reinforced soil structures in high-intensity seismic regions, this study systematically investigated the influence of different wrap-around facing types on the seismic performance of reinforced loess slopes ...
Zhicheng Zhao, Xin Huang, Xiaoguang Cai, Sihan Li, Honglu Xu, Jiayu Feng, Weixin Wang   +6 more
doaj   +1 more source

The origin and development of Garden cities: An overview [PDF]

Zbornik Radova: Geografski Fakultet Univerziteta u Beogradu, 2019
An overview of Garden City development as well as its significance in urban planning, are given in this paper. The Garden City idea, which had a major role in the 20th century urbanism, was born in London.
Gatarić Dragica, Belij Marija, Đerčan Bojan, Filipović Dejan   +3 more
doaj  

Rewriting and city structure

Festival dell'Architettura Magazine, 2021
Re-taking from literary practices the attitude of critically reworking formal characteristics belonging to something previous, rewriting offers itself as a possible technique for transforming parts of the city. This approach makes it possible to prevent mimetic results, highlighting conversely the substantial texture of the city, selecting its ...
openaire   +2 more sources