Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
The Family as a Constitutional Value in the Russian Federation
Сибирское юридическое обозрение, 2018 In the article the authors cover the problem of the constitutional and value content of the provisions of the Constitution of the Russian Federation, in particular, concerning the definition of the content of the constitutional-legal status of such an ...
A. V. Ageeva, S. L. Banshchikova
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
URDU-INCREASING TRENDS OF SUICIDE AND ITS PREVENTION IN THE LIGHT OF ISLAMIC TEACHINGS
دی اسکالرIslam believes that human life is a divine trust of Allah and it is a fundamental religious responsibility to protect it. Modern times have seen increasing suicide tendencies due to economic needs, loneliness, destruction of families, mental illnesses ...
Abdul Salam Tunio, Bashir Ahmed Rind
doaj
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Structure of TRAF Family: Current Understanding of Receptor Recognition
Frontiers in Immunology, 2018 Tumor necrosis factor receptor–associated factor (TRAF) proteins are key signaling molecules that function in various cellular signaling events including immune response, cell death and survival, development, and thrombosis.
Hyun H. Park
doaj +1 more source
Network structure of family function and self-management in patients with early chronic kidney disease amid the COVID-19 pandemic. [PDF]
Front Public Health, 2022 Cui Y +8 more
europepmc +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Transformation of Russian Family: History and Modern Trends
Вестник Кемеровского государственного университета. Серия: политические, социологические и экономические наукиIn modern Russia, the family institution is a matter of national security. This research featured the key transformations of the modern Russian family.
Tatiana N. Protasova
doaj +1 more source
Pengaruh Family Structure Terhadap Materialisme Dan Pembelian Kompulsif Pada Remaja
Jurnal Manajemen Teori dan Terapan, 2011 The main issue of this study is how family structure influences on consumer behavior. In this study both family structure intact, disrupted family structure and family structure associated with the attitude of materialism and compulsive buying with ...
Ristianawati Dwi Utami
doaj +1 more source