Results 111 to 120 of about 5,098,783 (294)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Anti-poverty campaign – the struggle between equality and efficiency

, 2011
Anti-poverty campaign – the struggle between equality and ...
Ferdinand Gul (13069785), Haitian Lu (11577586)   +1 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Putting Children First: New Frontiers in the Fight Against Child Poverty in Africa [PDF]

, 2019
Despite important strides in the fight against poverty in the past two decades, child poverty remains widespread and persistent, particularly in Africa.
Odunayo Akinyemi, Joshua, Munthali, Alister, Hagos, Adiam, Dolapo Somefun, Oluwaseyi, Odimegwu, Clifford, Emirie, Guday, Robson, Elsbeth, Mutiso, Stephen, Yadete, Workneh, Harman, Luke, Hassan, Billow, Bantebya‐Kyomuhendo, Grace, Zvobgo, Kerina, Farahat, Ahmed, Sulaiman, Munshi, Porter, Gina, Conklin, Sita, Marock, Carmel, Tefera, Bekele, Press, Sarah, Du Vent, Anna, Morgan, Richard, May, Julian, Coast, Ernestina, Akomolafe, Oluwatosin, Chase, Elaine, Isimbi, Roberte, Hall, Katherine, Kyoheirwe Muhanguzi, Florence, Tafere, Yisak, Woldehanna, Tassew, Roelen, Keetie, Ogawa, Marlene, Ngutuku, Elizabeth, Hypher, Nicola, Jones, Nicola, Pendlebury, Shirley, C. Sambu, Winnie, Jonah, Coretta, Umutoni, Marie Francoise, Hampshire, Kate, D'Sa, Nikhit, Tilahun, Kassahun, Araya, Mesele, Devereux, Stephen   +44 more
core  

Resistance on the battlefield: the lives of the marginalized in Capão Pecado

Travessias, 2020
This article proposes a reflection on the life and cultural representation of the marginalized in the work Capão Pecado de Ferréz, as well as the cultural relations that constitute conflicting dialogues.
Francinaldo Pereira da Silva, Lucélia de Sousa Almeida   +1 more
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

I. The Vow of Poverty as a Means to Overcome Poverty [PDF]

, 2008
I. The Vow of Poverty as a Means to Overcome Poverty -- 1.1 Intolerable Situations of Poverty -- (p. 2) -- 1.2 In the Light of the Gospel and Our Founders -- (p. 3) -- 1.3 The Struggle Against Poverty -- (p. 5) -- 1.4 Where Are We? -- (p.

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