Results 91 to 100 of about 4,523,760 (233)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

One Health clinic challenges and evolution: increasing access to care for people and pets in a rural community in Northern California

Frontiers in Veterinary Science
A student-run, free One Health clinic (OHC) improves access to care for people and pets while providing increased training opportunities for interprofessional students in the areas of spectrum of care, contextualized care, cultural humility, ethical ...
Kristin Jankowski, Kimberly Aguirre Siliezar, Jeannie A. Knuchell, Adrian Duenas-Ramirez, Jennifer J. Edwards, Jonathan D. Dear   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Responding to COVID-19: The experience of suppliers [PDF]

, 2020
Findings of the Institute of Student Employers survey of suppliers to the student employment market during the Covid-19 ...
Institute of Student Employers
core  

Qualitative Analysis of Peer Supervision Training Needs in a Student-Run Occupational Therapy Clinic

Journal of Occupational Therapy Education, 2019
The philosophy behind occupational therapy (OT) education espouses the belief that students are dynamic actors in the teaching-learning process, participating in self-appraisal and professional identity development. Yet, best-practice guidelines have not
Anne Murphy-Hagan, Lauren E. Milton
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Assessing Medical Student Attitudes Toward Intimate Partner Violence and Sexual Assault Following Protocol Training in a Student-Run Clinic Network

Background: Intimate Partner Violence (IPV) and Sexual Assault (SA) represent critical challenges in clinical settings, impacting patient safety and well-being.
Rajvi Kumar, Mahant Malempati
core   +1 more source

Review of student pharmacist-led patient assistance program services at a student-run free medical clinicKey Points

JAPhA Practice Innovations
Background: High medication costs in the United States can result in medication access challenges for underserved patients. These challenges may result in suboptimal outcomes (e.g., nonadherence and lower life expectancy).
Andrew A. Fritz, Sadie E. Pyle, Marilee D. Clemons, Jangus B. Whitner, Mitchell S. Howard   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source