Results 101 to 110 of about 17,261,047 (284)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

EFEKTIVITAS PEMANFAATAN FREE WEBLOG SEBAGAI CLASSROOM BLOGGING BERBASIS WEB DI JURUSAN TEKNIK ELEKTRO UNTUK MENINGKATKAN HASIL BELAJAR MAHASISWA

Jurnal Penelitian Pendidikan, 2012
One appropriate learning strategies to support e-learning, is a learning method Student Centered Learning (SCL). The term Student Centered Learning (SCL) is a method of learning and teaching in education wherein the student has responsibility for several
Sri Sartono, M. Harlanu, Agus Suryanto
doaj  

Integrating Scratch-assisted Project-based Learning Worksheets to Enhance Students' Mathematical Problem-Solving Skills and Dispositions

Jurnal Pedagogi dan Pembelajaran
The low level of student engagement in mathematics learning is attributed to the current generation of students being digital natives. While mathematics instruction still relies on 20th-century approaches or teacher-centered learning methods. This study
I Komang Adi Putra, Gede Suweken, I Gusti Putu Sudiarta   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Integrating the ASSURE Instructional Design Model in the Medical Education System: Applications in the Anatomy Discipline

Studia Universitatis Babeş-Bolyai. Psychologia-Paedagogia
The ASSURE model is a methodical framework that incorporates the study of learner characteristics, educational objectives, technology integration, resource selection and use, active student engagement, and ongoing evaluation.
Dan Alexandru SZABO, Ioan Alexandru BALMOS, Cristina VERES, Roxana Silvia TRUȚA, Tiberiu CONSTANTIN, Cosmina-Dumitrița LĂU-ANDRIEȘ, Heidrun ADUMITRACHIOAIE   +6 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Student-Centered Value Research: Assessment activities of the UNT Libraries [PDF]

, 2013
This presentation discusses student-centered value research and the assessment activities of the UNT Libraries. The UNT Libraries value research initiatives provide a means of measuring the Libraries' contribution to UNT's strategic ...
Brannon, Sian, Murray, Kathleen R.
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source