Results 171 to 180 of about 1,233,872 (313)

Development and evaluation of a mental health and suicide prevention student leadership training programme for secondary school students in Hong Kong. [PDF]

BMC Pediatr
Lui ID, Law TWS, Chung CL, Wong SSY, So WWY, Lee J, Yip PSF.   +6 more
europepmc   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Creating welcoming and courageous spaces for student leadership training. [PDF]

New Dir Stud Leadersh
Mayweather DJ.
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Integrating Planetary Health Into Medical Education: An ACC Medical Student Leadership Perspective. [PDF]

JACC Adv
Phillips-Wilson T, Khadke S, Mares A, Lawrence J, Shah J, Rajagopalan S, Al-Kindi S, Ganatra S.   +7 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Leadership in Private Christian Schools: Perceptions of Administrators

, 2012
The purpose of this exploratory qualitative study was to discover the perceptions of private Christian school administrators about leadership characteristics, roles, and teacher professional development.
Harrison, Suzanne
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Furthering Lifestyle Medicine Through the Donald A. Pegg Student Leadership Award: Reflections From 2023 Awardees. [PDF]

Am J Lifestyle Med
Jacob Y, Srinivasan R, Ubbens E, Orme A, Shahinfar S, Frates B.   +5 more
europepmc   +1 more source

Impact of a student leadership development program. [PDF]

Am J Pharm Educ, 2014
Wallace S.
europepmc   +1 more source