Results 61 to 70 of about 6,266,440 (333)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Analysing students’ mobility at higher education institutions: case of Ukrainian university during the war

open access: yesJournal of Business Economics and Management
Higher Education Institutions (HEIs) often overlook the importance of systematic data collection and analysis. This oversight can obscure critical trends and decision-making insights, particularly student mobility.
Nina Chala   +3 more
doaj   +1 more source

Studying abroad and the effect on international labor market mobility: evidence from the introduction of Erasmus [PDF]

open access: yes, 2007
We investigate the e¤ect of studying abroad on international labor market mobility later in life for German university graduates. As a source of identifying variation, we exploit the introduction and expansion of the ERASMUS student exchange program ...
Parey, Matthias, Waldinger, Fabian
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Student mobility and school segregation in an (un)controlled choice system: A counterfactual approach

open access: yesBritish Educational Research Journal, 2020
This article explores the relationship between school choice, student mobility and school segregation in Barcelona. The case of Barcelona is particularly interesting because the school admissions policy combines a particular design of catchment area with
Xavier Bonal   +2 more
semanticscholar   +1 more source

Developing (new) language skills through student mobility - the impact of an Erasmus+ experience [PDF]

open access: yesRevista de Știinţe Educaţiei, 2018
Language learning “folklore” has framed study abroad as one of the most efficient means of improving students` language competences. At the European level, Erasmus has been acting as the flagship student exchange programme for more than 30 years.
COJOCARU Florentina-Cristina
doaj   +1 more source

Shaping Asia Through Student Mobilities [PDF]

open access: yesAmerican Behavioral Scientist, 2020
While most Asian students still opt for Western universities when envisioning international destinations, growing numbers turn to Asian countries and their universities. This new development has received increasing attention among practitioners and policy makers, while social science research only recently turned to Asia-to-Asia students ...
openaire   +1 more source

Motivations and experiences of UK students studying abroad [PDF]

open access: yes, 2010
This report summarises the findings of research aimed at improving understanding of the motivations behind the international diploma mobility of UK ...
Ahrens, J   +7 more
core   +2 more sources

‘It was always the plan’ : international study as ‘learning to migrate’ [PDF]

open access: yes, 2016
International student mobility has mainly been theorised in terms of cultural capital accumulation and its prospective benefits on returning home following graduation. Yet, despite a growing body of work in this area, most research on post-study mobility
Findlay, Allan   +3 more
core   +1 more source

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