Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Enhancing student performance with multicolored 3D printed neuroanatomical models in veterinary education. [PDF]
BMC Med EducHadžiomerović N +8 more
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Comparison of JB4 plastic resin and standard paraffin methods on student performance and student perspectives in digital histology education: A randomized controlled study. [PDF]
Anat Sci EducŞahin İnan ZD, Ağadayı E.
europepmc +1 more source
The current study explores complex interplay between transformational, instructional, distributed leadership and student performance. Qualitative single descriptive case study research design which emanated from constructivist worldview was employed to ...
Shapaka, Rehabeam K.
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Impact of a Preclinical Elective on Medical Student Performance on an Anesthesiology Simulation Scenario. [PDF]
Adv Med Educ PractSawka DM +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Evaluating the effects of adjunct VR-haptic simulator practice in preclinical restorative training and predicting student performance using machine learning: a randomized controlled trial. [PDF]
BMC Med EducErsoz B +5 more
europepmc +1 more source
Prediction of student performance using dynamic machine learning models [PDF]
, 2021 Chrysogonidis, Georgios
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