Results 91 to 100 of about 753,988 (352)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

The U.S. Science and Technology Workforce [PDF]

open access: yes, 2008
[Excerpt] In the 21st century, global competition and rapid advances in science and technology will challenge the scientific and technical proficiency of the U.S. workforce.
Matthews, Christine M, Stine, Deborah D
core   +6 more sources

Why are male students less likely to opt for social science courses? : a theory-driven analysis [PDF]

open access: yes, 2020
Copyright © 2020 SageIn this article, we discuss the question of why only a few men decide to study social science courses such as social work. While the conceptual base of our analysis includes the theory of planned behaviour and theories centring on ...
Hadjar, Andreas, Haunberger, Sigrid
core   +1 more source

Modern approaches to the problem of values’ formation of students’ healthy lifestyle in the course of physical training

open access: yesPhysical Education of Students, 2018
Purpose : to prove, develop and check the model of values’ formation of a healthy lifestyle of students in the course of physical training. Material : students participated in an experiment (males - n=108; females - n=120; 18-20 years old).
Imas Y.V.ABCE   +5 more
semanticscholar   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Students Awareness of Health Teaching: Evaluation of "Health Education" Course and the Occupational Health Nursing Practice

open access: yesJournal of UOEH, 2003
The "health education" course is an important part of the baccalaureate curriculum in nursing. It is essential to teach students effective health education in a client oriented way. In order to improve the quality and content of this course, we extracted students descriptions from records of 44 students who had carried out group health education during
Junko, Horikawa   +2 more
openaire   +3 more sources

On the Sorting of Physicians across Medical Occupations [PDF]

open access: yes
We model the sorting of medical students across medical occupations and identify a mechanism that explains the possibility of differential productivity across occupations.
Courty, Pascal, Marschke, Gerald
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Is More Better? The Impact of Postsecondary Education on the Economic and Social Well-Being of American Society [PDF]

open access: yes, 2005
Provides a review of research literature that examines the impact of higher education on individuals and society. Looks at economic and non-economic benefits and costs associated with an increase in public investment in postsecondary ...
Adriane Williams, Watson Scott Swail
core  

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