Results 141 to 150 of about 11,635,652 (331)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Download the complete supplement in one PDF

open access: yesInternational Journal of Medical Students, 2013
International Journal of Medical Students
doaj   +6 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Experimental Medicine Biomedical Graduate Conference (AMBGC)

open access: yesMcGill Journal of Medicine, 2023
Experimental Medicine Graduate Students' Society (EMGSS)
doaj   +1 more source

Emotional Stability and Perception of Job Security in the Services Sector in Malaysia

open access: yesMalaysian Management Journal, 2004
Research pertaining to the perception of job security has focused primarily on attitudinal (e.g. job satisfaction), behavioral (e.g. employee turnover), and health outcomes, while research in the area of emotional stability has largely focused on ...
Kamarul Zaman Ahmad   +5 more
doaj  

Self-medication patterns among nursing students in North India

open access: bronze, 2013
Dept. of Pharmacology, MMIMSR, Mullana, Ambala, Haryana, India   +1 more
openalex   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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