Results 171 to 180 of about 9,718,538 (338)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The Current Studies of Education for a Traditional and Complementary Medicine in Malaysia. [PDF]

J Evid Based Complementary Altern Med, 2017
Kim YJ.
europepmc   +1 more source

Financial education in schools: A meta-analysis of experimental studies

Economics of Education Review, 2020
T. Kaiser, Lukas Menkhoff
semanticscholar   +1 more source

Social Mobility in Latin America: A Review of Existing Evidence [PDF]

This paper reviews evidence on social mobility in Latin America. Several studies have used data sets that collect intergenerational socio economic information.
Cesar Bouillon, Viviane Azevedo
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Study on Engineering Educational Accreditation Based on Outcome Based Education philosophy [PDF]

Advances in Social Science, Education and Humanities Research, 2021
Zhongyun Jiang, Fangqin Xu, Xia Zhu
openaire   +1 more source

The impact of education on economic growth: The case of Malaysia [PDF]

, 2007
This paper studies the relationship between education and economic growth in Malaysia. We examine the relationship between educational variables and gross domestic product (GDP).
Abdul Latif, Nurul Wahilah, Mohamed Yusof, Nor Yusma   +1 more
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

When Chilling Out Casts Doubt: Exploring the Temporal Associations Among Anxiety, Depression, and Cannabis Use in Emerging Adulthood

SAGE Open
Research shows that both cannabis use and emotional problems (anxiety and depression) tend to peak in emerging adulthood. There is a relative paucity of research examining the temporal associations between cannabis use and emotional problems among ...
Alison L. Rose, Alanna Single, Abby L. Goldstein, Joel O. Goldberg, Matthew T. Keough   +4 more
doaj   +1 more source