Results 111 to 120 of about 55,194,801 (312)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

VIR: from a small Bureau in the Russian Empire to the present-day National Center for Plant Genetic Resources

Genetic Resources
In 2024, the All-Russian Institute of Plant Genetic Resources (VIR), the world’s oldest scientific institution dedicated to plant genetic resources (PGR), celebrates its 130th anniversary. Founded as the Bureau of Applied Botany in the late 19th century,
Igor G Loskutov, Yulia V Ukhatova, Elena K Khlestkina   +2 more
doaj   +1 more source

The social representation of sexual violence between "background and surface attitudes" a research with university students

INFAD, 2016
The problem of "sexual violence", a central challenge of our society, keeps existing in spite of condamning stances from the institutions and the cultural world.
Maria Cardella, Orazio Licciardello, Claudia Castiglione, Grazia Di Marco   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Vocational Education and Training Workforce [PDF]

This Productivity Commission research report was released on 5 May 2011. This report, the first of a suite of three on the education and training workforce, focusses on the Vocational Education and Training workforce.
Commission, Productivity
core   +1 more source

2013 Report on the State of the Legal Market [PDF]

, 2013
As we enter 2013, the legal market continues in the fifth year of an unprecedented economic downturn that began in the third quarter of 2008. At this point, it is becoming increasingly apparent that the market for legal services in the United States and ...
Georgetown University Law Center, The Center for the Study of the Legal Profession
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The impact of detention on the health of asylum seekers: An updated systematic review: A systematic review

Campbell Systematic Reviews
Background The number of people fleeing persecution and regional conflicts is rising. Western countries have applied increasingly stringent measures to discourage those seeking asylum from entering their country, amongst them, to confine asylum seekers ...
Trine Filges, Elizabeth Bengtsen, Edith Montgomery, Malene Wallach Kildemoes   +3 more
doaj   +1 more source

Analytical and Comparative Study of Change in Functional Purpose of Some Archaeological and Historical Architectures in Cairo During the 19th and 20th Centuries [PDF]

, 2019
This research paper aims to discuss the nature of change in the functional purpose of some archaeological and historical buildings in Cairo during the 19th and 20th centuries along with a comparative study of some of the most important heritage ...
Khalifa, G. D. (Ghadeer)
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source