Results 181 to 190 of about 7,683,063 (318)

BIOINSPIRED CONCEPTUAL DESIGN (BICD): CONCEPTUAL DESIGN OF A GRASSHOPPER-LIKE JUMPING MECHANISM AS A CASE STUDY

, 2011
The evolution process of nature creates highly effective, power efficient, and perfectly structured biological systems. These excellent systems provide an inexhaustible source for engineers and scientists who desire to inspire ideas, processes ...
Erden, Abdulkadir, Eroğlu, Aylin Konez, Erden, Zühal   +2 more
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Tianjin Health and Chronic Disease Study (THCDS): study design and baseline characteristics of the cohort - cohort profile. [PDF]

BMJ Open
Li X, Miao Y, Zheng J, Zhang Y, Hao Y, Zhang N, Dai S, Lin W, Zhang Q.   +8 more
europepmc   +1 more source

Towards sustainable textile materials: Potential Pathways and Dialogues between Disciplines.

, 2019
The need to take care of our material environment has become urgent. New types of scientific collaboration have emerged, and designers are being invited to collaborate with top-level scientists.
Niinimäki, Kirsi, Kääriäinen, Pirjo
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Explainable AI for Well-Being Prediction From Lifestyle Data: 2-Study Design. [PDF]

JMIR Ment Health
Vancompernolle Vromman F, Vande Kerckhove C, Gagnon J, Pelletier C, Dufresne Y, Coulombe S.   +5 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Pain and Nutrition in Dementia and Alzheimer's Phase 1: a cross-sectional, observational study design. [PDF]

Front Dement
Judkins TC, Andrews HJ, Song Q, Clark EI, Tate C, Wais JI, Fillingim R, Huo Z, DeKosky ST, Gower B, Cohen RA, Ebner NC, Cruz-Almeida Y, Strath LJ.   +13 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The Danish National Survey of Diet and Physical Activity (DANSDA) 2021-2024: Study Design and Participants Characteristics. [PDF]

Nutrients
Christensen C, Biltoft-Jensen AP, Matthiessen J, Henriksen K, Sørensen MR, Christensen T, Trolle E, Fagt S.   +7 more
europepmc   +1 more source