Results 131 to 140 of about 5,990,468 (300)

The Impact of Demographic and Individual Heterogeneity on Unemployment Duration: A Regional Study [PDF]

Since 1992, claimant unemployment has fallen by almost 1½ million and on the ILO definition by nearly 1 million. Despite this fall, changes to the headline rate of unemployment masks a far more complex pattern of the UK?s unemployment experience.
William Collier
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Sarcopenia and sleep duration with the likelihood of successful aging among older adults in China: a prospective cohort study

BMC Geriatrics
Background Sarcopenia and sleep duration have emerged as crucial health-related factors in geriatric research. This study aimed to investigate the independent and joint associations of sarcopenia and sleep duration with successful aging and its ...
Bo Liang, Dingchun Hou, Jiajia Li, Gong Chen, Lijun Pei   +4 more
doaj   +1 more source

Interaction effect between sleep duration and dynapenic abdominal obesity for predicting functional disability: A longitudinal study

The Journal of Nutrition, Health and Aging
Objective: To assess the interaction of dynapenic abdominal obesity (DAO) and sleep duration on the risk of functional disability among middle-aged and older Chinese individuals.
Wenjin Han, Tianmeng Wang, Zhiqiang He, Yaping Wang, Caihua Wang, Shuangyan Lei, Xiaoqin Wang, Ronghua Wang   +7 more
doaj   +1 more source

A developmental study on a duration estimation

Japanese Psychological Research, 1989
Effects of frequency of intermittent sounds on duration estimation were examined with the subject of 155 children, from three to nine years of age, together with 20 adults.
openaire   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Study Site Planned Duration [PDF]

, 2020
openaire   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Mediation of the frailty index, the relationship between sleep duration and chronic pain in different body regions: insights from the CHARLS cross-sectional study

Journal of Orthopaedic Surgery and Research
Background Sleep duration and frailty index are knowm to influence chronic pain. However, the manner in which these factors interact to influence chronic pain remains unclear.
Changqing Li, Hong Ding, Lei Zhang, Chao Ma, Caiyun Ma, Hebao Wen, Xiaojiang Zhao   +6 more
doaj   +1 more source