Results 141 to 150 of about 5,990,468 (300)
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
A Review of Patient Waiting Time and Its Determinants in Emergency Departments in Iran [PDF]
بیمارستانBackground and purpose: This study aimed to review the average waiting time of patients referred to emergency departments in Iran and to identify the key factors influencing it. Methods: A systematic search was conducted in scientific databases including
Shahrzad Rasekhi +2 more
doaj
The importance of study duration and spatial scale in pathogen detection-evidence from a tick-infested island. [PDF]
Emerg Microbes Infect, 2018 Sormunen JJ +7 more
europepmc +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Association Between Sleep Duration and Dyslipidemia: Insights from a Large-Scale Cohort Study in Rural Iran [PDF]
Journal of Advanced Biomedical SciencesBackground & Objectives: Sleep duration is increasingly recognized as a critical determinant of overall health, particularly in relation to cardiovascular risk. Dyslipidemia, a leading contributor to cardiovascular disease, has been linked inconsistently
Zahra Rahpeyma +3 more
doaj
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Gastric emptying scintigraphy results in children are affected by age, anthropometric factors, and study duration. [PDF]
Neurogastroenterol Motil, 2015 Wong GK, Shulman RJ, Chumpitazi BP.
europepmc +1 more source