Results 71 to 80 of about 35,019,213 (291)

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The Influence of Multidimensional Situational Interest on Study Engagement in the University Physical Education Learning Environment in the Philippines

Sport i Turystyka
This study delved into the dynamics of situational interest in PE within the higher education environment of the Philippines, elucidating how SI can catalyse student engagement.
Joseph Lobo
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

‘Love, Love not’—a discovery of study engagement at higher education and the factors involved

Frontiers in Education
Taking that higher education is career-oriented, this study examines how Vietnamese undergraduate students engage with their study and how the factors related to the training program and occupation’s prospects contribute to students’ engagement with ...
Trang Thi Nhu Nguyen, Thai Thi Hong Bui, Lan Thi Nguyen, Hang Thuy Dao, Nguyen Lan Nguyen, Hanh Tuyet Mai, Ha Thi Thu Nguyen   +6 more
doaj   +1 more source

Design and rationale of the Engage-HF study: the impact of a gamified engagement toolkit on participation and engagement in a heart failure registry [PDF]

European Heart Journal - Digital Health
Abstract Aims Heart failure (HF) registries provide valuable insights into patient management and quality of care. However, healthcare professionals face challenges due to the administrative burden of participation in registries.
Abdul Shakoor, Chanu Mohansingh, Azzeddine El Osrouti, Jan Willem C Borleffs, Gert K van Houwelingen, Julio E C van de Swaluw, Roland van Kimmenade, Marjolein den Besten, Ron Pisters, Clara E E van Ofwegen-Hanekamp, Stefan Koudstaal, Louis M Handoko, Folkert W Asselbergs, Dennis van Veghel, Sandra S van Wijk, Robert M A van der Boon, Jasper J Brugts, Jeroen Schaap   +17 more
openaire   +3 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Firm innovations from voluntary dyadic engagement with nonprofit organisations: an exploratory UK study [PDF]

, 2010
This dissertation presents the findings of an exploratory collective case-study examining corporate innovations arising from voluntary dyadic engagement between UK firms and nonprofit organisations (NPOs) focused on social issues.
Holmes, Sara
core   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source