Results 91 to 100 of about 1,230,030 (294)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
International Journal of the First Year in Higher Education, 2014 The Feature in this issue is a conversation with Richard James, a highly respected Australian academic with extensive experience in research and policy development on the First Year Experience.
Karen Nelson, John Clarke, Tracy Creagh
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Advanced ElectromagneticsVisual communication of animation IP is an important link between content creation and audience reception. Under the development of intelligent production technologies, animation design is shifting from traditional manual production toward data-driven ...
W. Xu, W.-J. Jung
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Style-Shifting in Public New Perspectives on Stylistic Variation
Language acts are acts of identity, and linguistic variation reflects the multifaceted construction of verbal alternatives for transmitting social meaning, where style-shifting represents our ability to take up different social positions due to its ...
Hernández-Campoy, Juan Manuel. +1 more
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Style Shifting in a creole-speaking Community
, 2014 After a hiatus, the study of stylistic variation in speech has regained the attention of sociolinguists, but not so of scholars working on pidgin and creole languages, who tend to depend for data on intuitions, elicitations, or one-shot recordings in the field.
openaire +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Role of Headquarters Firms in Multinational Profit Shifting Strategies [PDF]
This paper stresses the special role of multinational headquarters in corporate profit shifting strategies. Using a large panel of European firms, we show that multinational enterprises (MNEs) are reluctant to shift profits away from their headquarters ...
Dischinger, Matthias, Riedel, Nadine
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