Results 251 to 260 of about 5,152,371 (378)
The Effects of Shoe Sole Thickness on Running Style and Stability During Downhill Running at Different Speeds. [PDF]
Kettner C, Stetter BJ, Stein T.
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Impact of landscape installation design on emotional loneliness: interaction style as a moderating factor. [PDF]
Gong M.
europepmc +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Enhanced Object Detection Algorithms in Complex Environments via Improved CycleGAN Data Augmentation and AS-YOLO Framework. [PDF]
Li Z, Wang Y, Meng L, Chu W, Yang G.
europepmc +1 more source
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Effects of Tai Chi on balance and fall prevention in healthy older adults: a randomized controlled meta-analysis. [PDF]
Dong R +4 more
europepmc +1 more source

