Results 131 to 140 of about 549,704 (368)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Foucaults Wende

open access: yesGenealogy+Critique, 2017
Michel Foucault's work and way of thinking of the late 1970s was marked by a fundamental turn, which was probably much more than the 'shift' he was speaking of at the very end of his life.
Philipp Sarasin
doaj   +2 more sources

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

Style-Friendly SNR Sampler for Style-Driven Generation [PDF]

open access: yesarXiv
Recent text-to-image diffusion models generate high-quality images but struggle to learn new, personalized styles, which limits the creation of unique style templates. In style-driven generation, users typically supply reference images exemplifying the desired style, together with text prompts that specify desired stylistic attributes.
arxiv  

First problem of globalization in the theory of dynamical systems admitting the normal shift of hypersurfaces [PDF]

open access: yesarXiv, 2001
Formula for the force field of Newtonian dynamical systems admitting the normal shift of hypersurfaces in Riemannian manifolds is considered. Problem of globalization for geometric structures associated with this formula is studied.
arxiv  

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Signing and Signifyin\u27: Negotiating Deaf and African American Identities [PDF]

open access: yes, 2007
For individuals who are both African American and Deaf finding a place to belong is a process of navigating their many cultural identities. In this paper I explore the following questions: where do individuals who are African American and Deaf find and ...
Clark, Heather D.
core   +1 more source

Challenging Assumptions in Learning Generic Text Style Embeddings [PDF]

open access: yesarXiv
Recent advancements in language representation learning primarily emphasize language modeling for deriving meaningful representations, often neglecting style-specific considerations. This study addresses this gap by creating generic, sentence-level style embeddings crucial for style-centric tasks.
arxiv  

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

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