Results 91 to 100 of about 39,415 (259)

Prognostic factors associated with length of stay in children with an acute admission to a pediatric ward: a historical cohort study

BMC Pediatrics
Background An acute (i.e. unplanned) admission implies uncertainty about the length of stay (LOS) for children, their parents and hospital staff. An improved understanding of the prognostic factors associated with LOS in children is essential for ...
Karlijn S. Timmer, Wieger P. Voskuijl, Merijn W. Bijlsma, Jolanda M. Maaskant   +3 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Do experiences and perceptions about quality of care differ among social groups in Nepal? : A study of maternal healthcare experiences of women with and without disabilities, and Dalit and non-Dalit women.

PLoS ONE, 2017
BackgroundSuboptimal quality of care and disparities in services by healthcare providers are often reported in Nepal. Experience and perceptions about quality of care may differ according to women's socio-cultural background, individual characteristics ...
Hridaya Raj Devkota, Andrew Clarke, Emily Murray, Nora Groce   +3 more
doaj   +1 more source

Mechanisms driving mesoscale latent heat flux variations and mixed layer heat content evaluation in the Northwest Tropical Atlantic [PDF]

Ocean Science
In this study, a high-resolution ocean-atmosphere coupled simulation is used to assess the effects of sea surface temperature (SST), surface currents, and ocean vertical stratification on the spatial variability of latent heat flux (LHF) and the ...
P. Fernández, P. Fernández, S. Speich, G. Lapeyre, C. Pasquero, C. Conejero, C. Conejero, L. Renault, F. Desbiolles   +8 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Has sentiment returned to the pre-pandemic level? A sentiment analysis using U.S. college subreddit data from 2019 to 2022.

PLoS ONE
BackgroundAs the impact of the COVID-19 pandemic winds down, both individuals and society are gradually returning to life and activities before the pandemic.
Tian Yan, Fang Liu
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Early adaptive schemas, emotional regulation, and cognitive flexibility in eating disorders: subtype specific predictors of eating disorder symptoms using hierarchical linear regression

Eating and Weight Disorders
Purpose Understanding how early adaptive schemas, cognitive flexibility, and emotional regulation influence eating disorder (ED) symptoms, and whether this differs across diagnostic subtypes is critical to optimising treatment.
J. S. Mitchell, T. Huckstepp, A. Allen, P. J. Louis, T. E. Anijärv, D. F. Hermens   +5 more
doaj   +1 more source

Characterizing Spatiotemporal Hydrological Responses During Extreme Flooding: A Residual Analysis Using SMAP Data

ISPRS International Journal of Geo-Information
Coarsely gridded Land Surface Models (LSMs) often smooth over sub-grid spatial heterogeneity and non-linear surface soil moisture dynamics during extreme-precipitation events.
Hashani Abeygunasekara, Badal Pokharel, Samsung Lim   +2 more
doaj   +1 more source