Results 91 to 100 of about 632,025 (310)

A phase 1 evaluation of inhaled oxytocin: Physiologically‐based pharmacokinetic model informed dosing of a novel heat‐stable oxytocin delivery system

British Journal of Clinical Pharmacology, EarlyView.
Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert, Carl M. J. Kirkpatrick, Rory Marriott, Siladitya Ray Chaudhuri, David Polidori, Bart Remmerie, Michelle P. McIntosh   +6 more
wiley   +1 more source

Maternal health service utilisation of adolescent women in sub-Saharan Africa: a systematic scoping review

BMC Pregnancy and Childbirth, 2019
Introduction Sub-Saharan Africa has the highest rate of adolescent pregnancy in the world. While pregnancy during adolescence poses higher risks for the mother and the baby, the utilisation of maternity care to mitigate the effects is low.
Tensae Mekonnen, Tinashe Dune, Janette Perz   +2 more
doaj   +1 more source

HLA genotype testing for carbamazepine, oxcarbazepine and eslicarbazepine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Carbamazepine is licensed in the United Kingdom for the treatment of epilepsy, bipolar disorder and trigeminal neuralgia. The related compounds oxcarbazepine and eslicarbazepine are licensed for the treatment of epilepsy. These drugs can cause immune‐mediated hypersensitivity reactions, which typically affect the skin, and can be of variable severity ...
Lucy Galloway, Cinzia Dello Russo, Nicholas Bass, Elvira Bramon, Helen Cross, Natalie Curley, Sarah Curran, Helen Davies, Jana De Villiers, William Evans, Bernhard Frank, Alice Groves, Judith Hayward, Jon Higham, Dyfrig A. Hughes, Shwe Sin Kyaw, Anthony G. Marson, Ailsa McLellan, Seth Mensah, Francis O'Neill, Jane Sargison, Sanjay M. Sisodiya, Jill Swan, Joanna M. Zakrewska, Munir Pirmohamed   +24 more
wiley   +1 more source

Does Africa really benefit from trade? [PDF]

We empirically analyse the impact of trade on income levels in the sub-Saharan African countries. The results indicate that the linkage between these two variables is negative for these countries.
Busse, Matthias, Groizard, José Luis
core  

Global and regional knowledge of antibiotic use and resistance among healthcare students: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims We synthesized and analysed existing evidence on healthcare students' knowledge of antibiotic use and resistance to provide pooled global and regional estimates. Methods The PubMed®, Embase® and CINAHL databases were searched for studies published between January 2015 and October 2025 that reported the knowledge of antibiotic use and resistance ...
Asa Auta, Erick Wesley Hedima, Emmanuel O. Adewuyi, Shalkur David, Emmanuel Agada David, Lomikga Balachandran, Enoche Florence Oga, Davies Adeloye, Barry Strickland‐Hodge   +8 more
wiley   +1 more source

An Investigation into the Level of Financial Inclusion in Sub-Saharan Africa

Scientific Annals of Economics and Business, 2019
Financial inclusion is crucial for redistribution of economic resources between the deficit and surplus units in an economy. Despite the importance of financial inclusion, especially for economic growth of developing regions such as Sub-Saharan Africa ...
Abdulmumin Biliqees Ayoola, Etudaiye-Muhtar Oyebola Fatima, Jimoh Abdulrasaq Taiye, Sakariyahu Ola Ridwan   +3 more
doaj   +1 more source

ACKR1/Duffy‐null genotype testing for clozapine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Abstract Clozapine is licenced for treatment‐resistant schizophrenia and psychosis in Parkinson's disease. In the United Kingdom, there is a mandatory requirement for absolute neutrophil count (ANC) and white blood cell count (WBC) monitoring to safeguard against agranulocytosis.
Stephen Murtough, Oriella Stellakis, Daisy Mills, Blanca Bjourson, Vicky Chaplin, Dharmisha Chauhan, Bev Chipp, Marius Cotic, Jana de Villiers, Olubanké Dzahini, Frances Elmslie, Katie Evans, Shreyans Gandhi, Dyfrig A. Hughes, Huajie Jin, Daniele Panconesi, Anna Skowronska, Sanjay M. Sisodiya, Ed Silva, Vicky Stinton, Sara Stuart‐Smith, Sarah Tarrant, David Taylor, Lauren Varney, James T. R. Walters, Michelle Wood, Jessica Woodley, Cinzia Dello Russo, Munir Pirmohamed, Elvira Bramon   +29 more
wiley   +1 more source

Economy-wide Impacts of Climate on Agriculture in Sub-Saharan Africa [PDF]

Two possible adaptation options to climate change for Sub-Saharan Africa are analyzed under the SRES B2 scenario. The first scenario doubles irrigated areas in Sub-Saharan Africa by 2050, compared to the baseline, but keeps total crop area constant.
Alvaro Calzadilla, Claudia Ringler, Katrin Rehdanz, Richard S.J. Tol, Tingju Zhu   +4 more
core  

On the impact of early marriage on schooling outcomes in sub-Saharan Africa and South West Asia [PDF]

, 2015
This paper examines the effect of age of marriage on women's schooling outcomes for 36 countries from Sub-Saharan Africa and South West Asia. We employ an instrumental variable approach to account for the endogeneity of early marriage driven by socio ...
Akyeampong, Kwame, Delprato, Marcos, Hernandez-Fernandez, Jimena, Sabates, Ricardo   +3 more
core   +2 more sources

Understanding the paradox of primary teacher shortage in low‐income countries: Insights from Malawi

British Educational Research Journal, EarlyView.
Abstract Malawi faces a persistent and chronic teacher shortage, particularly at the primary school level, with much of the challenge attributed to teacher supply constraints. While the causes of teacher shortages are known to be complex and context‐dependent, there remains a lack of in‐depth, country‐specific research to guide effective policies ...
Peter Mtika, Edward M. Sosu
wiley   +1 more source